Selection of biologically active peptides by phage display of random peptide libraries

被引：105
|
作者：
Cortese, R
Monaci, P
Luzzago, A
Santini, C
Bartoli, F
Cortese, I
Fortugno, P
Galfre, G
Nicosia, A
Felici, F
机构：
[1] UNIV ROMA TOR VERGATA, NEUROL CLIN, I-00179 ROME, ITALY
[2] CLIN S LUCIA, I-00179 ROME, ITALY
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1996年 / 7卷 / 06期
关键词：
D O I：
10.1016/S0958-1669(96)80072-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Random peptide libraries displayed on phage are used as a source of peptides for epitope mapping, for the identification of critical amino acids responsible for protein-protein interactions and as leads for the discovery of new therapeutics. Efficient and simple procedures have been devised to select peptides binding to purified proteins, to monoclonal and polyclonal antibodies and to cell surfaces in vivo and in vitro. (C) Current Biology Ltd ISSN 0958-1669.
引用
收藏
页码：616 / 621
页数：6
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