Pathophysiological role of ion channels and transporters in HER2-positive breast cancer

被引：4

作者：

Zhou, Zhengxing ^{[1
]}

Zhang, Chengmin ^{[1
]}

Ma, Zhiyuan ^{[2
]}

Wang, Hu ^{[1
]}

Tuo, Biguang ^{[2
]}

Cheng, Xiaoming ^{[1
]}

Liu, Xuemei ^{[2
]}

Li, Taolang ^{[1
]}

机构：

[1] Zunyi Med Univ, Affiliated Hosp, Dept Thyroid & Breast Surg, Zunyi 563003, Guizhou, Peoples R China

[2] Zunyi Med Univ, Affiliated Hosp, Dept Gastroenterol, Zunyi 563003, Guizhou, Peoples R China

来源：

CANCER GENE THERAPY | 2022年 / 29卷 / 8-9期

基金：

中国国家自然科学基金;

关键词：

MAMMARY-TUMOR GROWTH; COTRANSPORTER NBCN1; SIGNAL-TRANSDUCTION; PROGNOSTIC MARKER; ACTIVITY PROMOTES; EXPRESSION; CELLS; RECEPTOR; PROTEIN; HER2;

D O I：

10.1038/s41417-021-00407-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The incidence of breast cancer (BC) has been increasing each year, and BC is now the most common malignant tumor in women. Among the numerous BC subtypes, HER2-positive BC can be treated with a variety of strategies based on targeting HER2. Although there has been great progress in the treatment of HER2-positive BC, recurrence, metastasis and drug resistance remain considerable challenges. The dysfunction of ion channels and transporters can affect the development and progression of HER2-positive BC, so these entities are expected to be new therapeutic targets. This review summarizes various ion channels and transporters associated with HER2-positive BC and suggests potential targets for the development of new and effective therapies.

引用

页码：1097 / 1104

页数：8

共 129 条

[1]

Agre Peter, 2006, Proc Am Thorac Soc, V3, P5, DOI 10.1513/pats.200510-109JH

[2] The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms [J].

Andersen, Anne Poder ;

Samsoe-Petersen, Jacob ;

Oernbo, Eva Kjer ;

Boedtkjer, Ebbe ;

Moreira, Jose M. A. ;

Kveiborg, Marie ;

Pedersen, Stine Falsig .

INTERNATIONAL JOURNAL OF CANCER, 2018, 142 (12) :2529-2542

[3] Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment [J].

Andersen, Anne Poder ;

Moreira, Jose M. A. ;

Pedersen, Stine Falsig .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2014, 369 (1638)

[4] MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation [J].

Assiri, Abdullah A. ;

Mourad, Noha ;

Shao, Minghai ;

Kiel, Patrick ;

Liu, Wanqing ;

Skaar, Todd C. ;

Overholser, Brian R. .

CANCER GENOMICS & PROTEOMICS, 2019, 16 (06) :433-442

[5] ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines [J].

Ayoub, C. ;

Wasylyk, C. ;

Li, Y. ;

Thomas, E. ;

Marisa, L. ;

Robe, A. ;

Roux, M. ;

Abecassis, J. ;

de Reynies, A. ;

Wasylyk, B. .

BRITISH JOURNAL OF CANCER, 2010, 103 (05) :715-726

[6] Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival [J].

Baenke, Franziska ;

Dubuis, Sebastien ;

Brault, Charlene ;

Weigelt, Britta ;

Dankworth, Beatrice ;

Griffiths, Beatrice ;

Jiang, Ming ;

Mackay, Alan ;

Saunders, Becky ;

Spencer-Dene, Bradley ;

Ros, Susana ;

Stamp, Gordon ;

Reis-Filho, Jorge S. ;

Howell, Michael ;

Zamboni, Nicola ;

Schulze, Almut .

JOURNAL OF PATHOLOGY, 2015, 237 (02) :152-165

[7] NF-κB Activation-Induced Anti-apoptosis Renders HER2-Positive Cells Drug Resistant and Accelerates Tumor Growth [J].

Bailey, Shannon T. ;

Miron, Penelope L. ;

Choi, Yoon J. ;

Kochupurakkal, Bose ;

Maulik, Gautam ;

Rodig, Scott. J. ;

Tian, Ruiyang ;

Foley, Kathleen M. ;

Bowman, Teresa ;

Miron, Alexander ;

Brown, Myles ;

Iglehart, J. Dirk. ;

Biswas, Debajit K. .

MOLECULAR CANCER RESEARCH, 2014, 12 (03) :408-420

[8] Capacitative calcium influx in human epithelial breast cancer and non-tumorigenic cells occurs through Ca2+ entry pathways with different permeabilities to divalent cations [J].

Baldi, C ;

Vazquez, G ;

Boland, R .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2003, 88 (06) :1265-1272

[9] NHERF1/EBP50 in Breast Cancer: Clinical Perspectives [J].

Bellizzi, Antonia ;

Malfettone, Andrea ;

Cardone, Rosa A. ;

Mangia, Anita .

BREAST CARE, 2010, 5 (02) :86-90

[10] Calcium signalling: Dynamics, homeostasis and remodelling [J].

Berridge, MJ ;

Bootman, MD ;

Roderick, HL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529

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