A long-lasting, complete hematologic and cytogenetic remission of chronic myelogenous leukemia after treatment with busulfan alone

被引：2
作者：
Mandigers, CMPW
Mensink, EJBM
van Kessel, AG
van der Plas, DC
Haanen, C
Hagemeÿer, A
de Witte, T
机构：
[1] Univ Nijmegen Hosp, Dept Hematol 544, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen Hosp, Dept Anthropogenet, NL-6500 HB Nijmegen, Netherlands
[3] Erasmus Univ, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands
来源：
ANNALS OF HEMATOLOGY | 1996年 / 72卷 / 06期
关键词：
busulfan; chronic myelogenous leukemia; cytogenetic; minimal residual disease; polymerase chain reaction;
D O I：
10.1007/s002770050188
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 44-year-old man suffering from cytogenetically and molecularly proven Philadelphia translocation-positive chronic myelogenous leukemia in chronic phase was treated with busulfan for 18 months and studied during a follow-up period of 13 years. Hematologically and cytogenetically, he attained a continuing complete remission, although at one point (9.5 years) at least, after attaining complete remission molecular analysis indicated the presence of minimal residual disease.
引用
收藏
页码：371 / 373
页数：3
相关论文
共 14 条
  • [1] BARR BMA, 1993, J CLIN ONCOL, V11, P513
  • [2] DEWITTE T, 1985, SCAND J HAEMATOL, V3, P421
  • [3] DREAZEN O, 1988, SEMIN HEMATOL, V25, P35
  • [4] SPONTANEOUS REMISSION IN A PATIENT WITH CHRONIC MYELOID-LEUKEMIA
    FEGAN, C
    MORGAN, G
    WHITTAKER, JA
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1989, 72 (04) : 594 - 595
  • [5] GALTON DAG, 1969, SEMIN HEMATOL, V6, P323
  • [6] BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKEMIA IN CHRONIC PHASE - INCREASED RISK FOR RELAPSE ASSOCIATED WITH T-CELL DEPLETION
    GOLDMAN, JM
    GALE, RP
    HOROWITZ, MM
    BIGGS, JC
    CHAMPLIN, RE
    GLUCKMAN, E
    HOFFMANN, RG
    JACOBSEN, SJ
    MARMONT, AM
    MCGLAVE, PB
    MESSNER, HA
    RIMM, AA
    ROZMAN, C
    SPECK, B
    TURA, S
    WEINER, RS
    BORTIN, MM
    [J]. ANNALS OF INTERNAL MEDICINE, 1988, 108 (06) : 806 - 814
  • [7] GRIFFIN JD, 1986, SEMIN HEMATOL, V23, P20
  • [8] RANDOMIZED COMPARISON OF BUSULFAN AND HYDROXYUREA IN CHRONIC MYELOGENOUS LEUKEMIA - PROLONGATION OF SURVIVAL BY HYDROXYUREA
    HEHLMANN, R
    HEIMPEL, H
    HASFORD, J
    KOLB, HJ
    PRALLE, H
    HOSSFELD, DK
    QUEISSER, W
    LOFFLER, H
    HEINZE, B
    GEORGII, A
    VONWUSSOW, P
    BARTRAM, C
    GRIESSHAMMER, M
    BERGMANN, L
    ESSERS, U
    FALGE, C
    HOCHHAUS, A
    QUEISSER, U
    SICK, C
    MEYER, P
    SCHMITZ, N
    VERPOORT, K
    EIMERMACHER, H
    WALTHER, F
    WESTERHAUSEN, M
    KLEEBERG, UR
    HEILEIN, A
    KABISCH, A
    BARZ, C
    ZIMMERMANN, R
    MEURET, G
    TICHELLI, A
    BERDEL, WE
    KANZ, L
    ANGER, B
    TIGGES, FJ
    SCHMID, L
    BROCKHAUS, W
    ZANKOVICH, R
    SCHLAFER, U
    WEISSENFELS, I
    MAINZER, K
    TOBLER, A
    PERKER, M
    HOHNLOSER, J
    MESSENER, D
    THIELE, J
    BUHR, T
    ANSARI, H
    [J]. BLOOD, 1993, 82 (02) : 398 - 407
  • [9] NAJEAN Y, 1991, LEUKEMIA, V5, P621
  • [10] PRISCHL FC, 1989, BRIT J HAEMATOL, V71, P337
12