PBX proteins: much more than Hox cofactors

被引：82

作者：

Laurent, Audrey ^{[1
]}

Bihan, Rejane ^{[1
]}

Omilli, Francis ^{[1
]}

Deschamps, Stetphane ^{[1
]}

Pellerin, Isabelle ^{[1
]}

机构：

[1] Univ Rennes, CNRS,IGDR, UMR 6061, IFR 140, F-35043 Rennes, France

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2008年 / 52卷 / 01期

关键词：

PBX; Hox; homeodomain; cofactors;

D O I：

10.1387/ijdb.072304al

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pre-B cell leukaemia transcription factors (PBXs) were originally identified as Hox cofactors, acting within transcriptional regulation complexes to regulate genetic programs during development. Increasing amount of evidence revealed that PBX function is not restricted to a partnership with Hox or homeodomain proteins. Indeed, PBXs are expressed throughout murine embryonic development and are involved in several developmental pathways including Hox-independent mechanisms. This review summarizes what is known about PBX partnerships and proposes to position PBXs as central developmental factors whose role consists of integrating transduction signals, in order to regulate gene expression programs during development.

引用

页码：9 / 20

页数：12

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