Antiparasitic Effects of Sulfated Polysaccharides from Marine Hydrobionts

被引：12
作者：
Besednova, Natalya N. [1 ]
Zaporozhets, Tatyana S. [1 ]
Andryukov, Boris G. [1 ,2 ]
Kryzhanovsky, Sergey P. [3 ]
Ermakova, Svetlana P. [4 ]
Kuznetsova, Tatyana A. [1 ]
Voronova, Anastasia N. [1 ]
Shchelkanov, Mikhail Y. [1 ,2 ,5 ,6 ]
机构：
[1] GP Somov Res Inst Epidemiol & Microbiol, Fed Serv Surveillance Consumer Rights Protect & H, Vladivostok 690087, Russia
[2] Far Eastern Fed Univ FEFU, Sch Biomed, Vladivostok 690091, Russia
[3] Russian Acad Sci, Far Eastern Branch, Med Assoc, Vladivostok 690022, Russia
[4] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia
[5] Russian Acad Sci, Far Eastern Branch, Natl Sci Ctr Marine Biol, Vladivostok 690041, Russia
[6] Russian Acad Sci, Far Eastern Branch, Fed Sci Ctr East Asia Terr Biodivers, Vladivostok 690022, Russia
来源：
MARINE DRUGS | 2021年 / 19卷 / 11期
关键词：
sulfated polysaccharides; marine hydrobionts; antiparasitic activity; protozoa; malaria; leishmaniasis; trypanosomiasis; schistosomiasis; cryptosporidiosis; trichomoniasis; FUCOSYLATED CHONDROITIN SULFATE; PLASMODIUM-FALCIPARUM; HOST-CELL; IN-VITRO; ANTICOAGULANT ACTIVITY; LEISHMANIA-DONOVANI; FUCOIDAN; PROTEINS; HEPARIN; TOXOPLASMA;
D O I：
10.3390/md19110637
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This review presents materials characterizing sulfated polysaccharides (SPS) of marine hydrobionts (algae and invertebrates) as potential means for the prevention and treatment of protozoa and helminthiasis. The authors have summarized the literature on the pathogenetic targets of protozoa on the host cells and on the antiparasitic potential of polysaccharides from red, brown and green algae as well as certain marine invertebrates. Information about the mechanisms of action of these unique compounds in diseases caused by protozoa has also been summarized. SPS is distinguished by high antiparasitic activity, good solubility and an almost complete absence of toxicity. In the long term, this allows for the consideration of these compounds as effective and attractive candidates on which to base drugs, biologically active food additives and functional food products with antiparasitic activity.
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页数：25
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