PROX1 is a predictor of survival for gliomas WHO grade II

被引：38
作者：
Elsir, T. [2 ]
Qu, M. [1 ,2 ]
Berntsson, S. G. [1 ]
Orrego, A. [2 ]
Olofsson, T. [3 ]
Lindstrom, M. S. [2 ]
Nister, M. [2 ]
von Deimling, A. [4 ,5 ]
Hartmann, C. [4 ,5 ]
Ribom, D. [1 ]
Smits, A. [1 ]
机构：
[1] Uppsala Univ, Dept Neurosci, S-75185 Uppsala, Sweden
[2] Karolinska Univ Hosp, Dept Oncol Pathol, Karolinska Inst, CCK R8 05, S-17176 Stockholm, Sweden
[3] Natl Board Forens Med, S-75140 Uppsala, Sweden
[4] Heidelberg Univ, Dept Neuropathol, Inst Pathol, D-69120 Heidelberg, Germany
[5] German Canc Res Ctr, Clin Cooperat Unit Neuropathol, D-69120 Heidelberg, Germany
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 11期
基金：
瑞典研究理事会;
关键词：
low-grade glioma; astrocytoma; oligodendroglioma; PROX1; prognosis; survival; PROGNOSTIC FACTORS; MANAGEMENT; EFFICACY; ADULT; RADIOTHERAPY;
D O I：
10.1038/bjc.2011.162
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcription factor that has a critical role in the development of various organs. PROX1 has been ascribed both oncogenic and tumour suppressive functions in human cancers. We have recently shown that PROX1 may act as a diagnostic marker for high-grade gliomas. The aim of this study was to address the prognostic value of PROX1 in grade II gliomas. METHODS: A total of 116 samples were evaluated for the presence of PROX1 protein. The number of immunopositive cells was used as a variable in survival analysis, together with established prognostic factors for this patient group. RESULTS: Higher PROX1 protein was associated with poor outcome. In the multivariate analysis, PROX1 was identified as an independent factor for survival (P = 0.024), together with the presence of mutated isocitrate dehydrogenase 1 R132H protein, and with combined losses of chromosomal arms 1p/19q in oligodendrocytic tumours. CONCLUSION: PROX1 is a novel predictor of survival for grade II gliomas. British Journal of Cancer (2011) 104, 1747-1754. doi:10.1038/bjc.2011.162 www.bjcancer.com Published online 10 May 2011 (C) 2011 Cancer Research UK
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页码：1747 / 1754
页数：8
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