Vitamin D in autoimmune bullous diseases

被引:6
作者
Tukaj, Stefan [1 ]
机构
[1] Univ Gdansk, Dept Mol Biol, Fac Biol, Gdansk, Poland
关键词
calcitriol; 1,25(OH)(2)D-3; vitamin D; 25(OH)D; autoimmune bullous diseases; HAILEY-HAILEY-DISEASE; KAPPA-B ACTIVITY; D DEFICIENCY; T-CELLS; P450SCC; PATHOPHYSIOLOGY; AUTOANTIBODIES; KERATINOCYTES; INFLAMMATION; ASSOCIATION;
D O I
10.18388/abp.2020_2905
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Numerous epidemiological studies have suggested a link between vitamin D deficiency and the development of various autoimmune diseases, including diabetes mellitus type 1, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis or systemic lupus erythematosus. More recently, such a link has been also proposed for autoimmune bullous diseases (AIBD). This is a relatively rare and potentially life-threatening, organspecific group of inflammatory skin diseases characterized by the presence of tissue-bound and circulating autoantibodies against various molecules present in desmosomes (in pemphigus diseases) or hemidesmosomes (in pemphigoid diseases). In addition to the well-known role of vitamin D in calcium and phosphate homeostasis, the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D-3 (calcitriol), exerts potent effects on cellular differentiation and regulation of immune responses via binding to the vitamin D receptor present in most cells of the immune system. Since cells of both, the innate and adaptive immune systems, are known to be relevant in AIBD, the role of vitamin D analogues in the treatment of patients with these disorders deserves much attention. This mini-review summarizes recent epidemiological and experimental studies on vitamin D involvement in the autoimmune bullous diseases.
引用
收藏
页码:1 / 5
页数:5
相关论文
共 52 条
[1]   Treatment of Hailey-Hailey disease with topical calcitriol [J].
Bianchi, L ;
Chimenti, MS ;
Giunta, A .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 51 (03) :475-476
[2]   In vitro and in vivo models to investigate the pathomechanisms and novel treatments for pemphigoid diseases [J].
Bieber, Katja ;
Koga, Hiroshi ;
Nishie, Wataru .
EXPERIMENTAL DERMATOLOGY, 2017, 26 (12) :1163-1170
[3]   Regulatory T Cells Suppress Inflammation an Blistering in Pemphigold Diseases [J].
Bieber, Katja ;
Sun, Shijie ;
Witte, Mareike ;
Kasprick, Anika ;
Beltsiou, Foteini ;
Behnen, Martina ;
Laskay, Tamas ;
Schulze, Franziska S. ;
Pipi, Elena ;
Reichhelm, Niklas ;
Pagel, Rene ;
Zillikens, Detlef ;
Schmidt, Enno ;
Sparwasser, Tim ;
Kalies, Kathrin ;
Ludwig, Ralf J. .
FRONTIERS IN IMMUNOLOGY, 2017, 8
[4]   T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita [J].
Bieber, Katja ;
Witte, Mareike ;
Sun, Shijie ;
Hundt, Jennifer E. ;
Kalies, Kathrin ;
Draeger, Soeren ;
Kasprick, Anika ;
Twelkmeyer, Trix ;
Manz, Rudolf A. ;
Koenig, Peter ;
Koehl, Joerg ;
Zillikens, Detlef ;
Ludwig, Ralf J. .
SCIENTIFIC REPORTS, 2016, 6
[5]   Vitamin D Metabolism, Mechanism of Action, and Clinical Applications [J].
Bikle, Daniel D. .
CHEMISTRY & BIOLOGY, 2014, 21 (03) :319-329
[6]   Vitamin D and Bone [J].
Bikle, Daniel D. .
CURRENT OSTEOPOROSIS REPORTS, 2012, 10 (02) :151-159
[7]   Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms [J].
Chaiprasongsuk, Anyamanee ;
Janjetovic, Zorica ;
Kim, Tae-Kang ;
Jarrett, Stuart G. ;
D'Orazio, John A. ;
Holick, Michael F. ;
Tang, Edith K. Y. ;
Tuckey, Robert C. ;
Panich, Uraiwan ;
Li, Wei ;
Slominski, Andrzej T. .
REDOX BIOLOGY, 2019, 24
[8]   IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid [J].
Chakievska, Lenche ;
Holtsche, Maike M. ;
Kuenstner, Axel ;
Goletz, Stephanie ;
Petersen, Britt-Sabina ;
Thaci, Diamant ;
Ibrahim, Saleh M. ;
Ludwig, Ralf J. ;
Franke, Andre ;
Sadik, Christian D. ;
Zillikens, Detlef ;
Hoelscher, Christoph ;
Busch, Hauke ;
Schmidt, Enno .
JOURNAL OF AUTOIMMUNITY, 2019, 96 :104-112
[9]   Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential [J].
Dankers, Wendy ;
Colin, Edgar M. ;
van Hamburg, Jan Piet ;
Lubberts, Erik .
FRONTIERS IN IMMUNOLOGY, 2017, 7
[10]   Vitamin D: its role and uses in immunology [J].
Deluca, HF ;
Cantorna, MT .
FASEB JOURNAL, 2001, 15 (14) :2579-2585