Carriage of Haemophilus influenzae among Brazilian children attending day care centers in the era of widespread Hib vaccination

被引：19

作者：

de Carvalho, Camila Xavier ^{[2
]}

Kipnis, Andre ^{[2
]}

Thoern, Licia ^{[3
]}

de Andrade, Joao Guimaraes ^{[4
]}

Pimenta, Fabiana ^{[5
]}

de Cunto Brandileone, Maria Cristina ^{[6
]}

Zanella, Rosemeire Cobo ^{[6
]}

Flannery, Brendan ^{[7
]}

Sgambatti, Sabrina ^{[8
]}

Andrade, Ana Lucia ^{[1
]}

机构：

[1] Univ Fed Goias, Dept Community Hlth, Inst Trop Pathol & Publ Hlth, BR-74605050 Goiania, Go, Brazil

[2] Univ Fed Goias, Lab Mol Bacteriol, Inst Trop Pathol & Publ Hlth, BR-74605050 Goiania, Go, Brazil

[3] Secretary Hlth Goiania, Div Epidemiol, Goiania, Go, Brazil

[4] Univ Fed Goias, Dept Trop Med & Dermatol, Inst Trop Pathol & Publ Hlth, BR-74605050 Goiania, Go, Brazil

[5] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Atlanta, GA USA

[6] Secretary Hlth State Sao Paulo, Inst Adolfo Lutz, Bacteriol Branch, Sao Paulo, Brazil

[7] Pan Amer Hlth Org, Brasilia, DF, Brazil

[8] Catolica Univ Goias, Dept Med, Goiania, Go, Brazil

来源：

VACCINE | 2011年 / 29卷 / 07期

关键词：

H. influenzae carriage; Hib vaccination; Nontypeable H. influenzae; ACUTE OTITIS-MEDIA; B CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; BETA-LACTAMASES; EPIDEMIOLOGIC CHARACTERISTICS; NASOPHARYNGEAL COLONIZATION; CHANGING EPIDEMIOLOGY; INVASIVE DISEASE; PROTEIN-D; PATHOGENS;

D O I：

10.1016/j.vaccine.2010.12.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Haemophilus influenzae type b vaccine was introduced into the Immunization Program of Brazil in 1999 and no study has evaluated the impact of Hib vaccination in H. influenzae carriage so far. In June 2010, Brazil introduced the 10-valent pneumococcal nontypeable H. influenzae (NTHi) conjugate vaccine (PHiD-CV). We investigated the prevalence of encapsulated H. influenzae and NTHi isolates in nasopharyngeal samples of 1192 children attending day-care centers in Goiania, central Brazil. H. influenzae carriage rate was 32.1% and 38.4% of them carried beta-lactamase TEM-1 gene. Serotype f (4.6%) was the most frequent encapsulated isolate, type b was recovered in only 0.7% and carriage rate of NTHi was 23.3%. Recurrent acute otitis media and NTHi were independently associated with colonization by beta-lactamase producing H. influenzae. Changes in frequency of H. influenzae carriage isolates should be carefully monitored to assess the impact of the PHiD-CV on NTHi carriage in young children. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1438 / 1442

页数：5

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