Synthesis of monodisperse biodegradable microgels in microfluidic devices

被引：138
作者：
De Geest, BG
Urbanski, JP
Thorsen, T
Demeester, J
De Smedt, SC
机构：
[1] State Univ Ghent, Lab Gen Biochem & Phys Pharm, Dept Pharmaceut, B-9000 Ghent, Belgium
[2] MIT, Dept Mech Engn, Hatsopoulos Microfluids Lab, Cambridge, MA 02139 USA
来源：
LANGMUIR | 2005年 / 21卷 / 23期
关键词：
D O I：
10.1021/la051527y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 mu m sized monodisperse microgels by emulsifying an aqueous dextran-hydroxyethyl methacrylate (dex-HEMA) phase within an oil phase at the junction of microfluidic channels. Dex-HEMA microgels are biodegradable and are ideally suited for the controlled delivery of proteins.
引用
收藏
页码：10275 / 10279
页数：5
相关论文
共 27 条
  • [1] Albertsson P.A., 1986, PARTITION CELL PARTI
  • [2] Cadée JA, 2000, J BIOMED MATER RES, V50, P397
  • [3] Charcosset C, 2005, REV CHEM ENG, V21, P1
  • [4] GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH
    CHEN, GH
    HOFFMAN, AS
    [J]. NATURE, 1995, 373 (6509) : 49 - 52
  • [5] In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts
    De Groot, CJ
    Van Luyn, MJA
    Van Dijk-Wolthuis, WNE
    Cadée, JA
    Plantinga, JA
    Den Otter, W
    Hennink, WE
    [J]. BIOMATERIALS, 2001, 22 (11) : 1197 - 1203
  • [6] DEGEEST B, IN PRESS J ADV MAT
  • [7] Controlled synthesis of nonspherical microparticles using microfluidics
    Dendukuri, D
    Tsoi, K
    Hatton, TA
    Doyle, PS
    [J]. LANGMUIR, 2005, 21 (06) : 2113 - 2116
  • [8] Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres
    Franssen, O
    Vandervennet, L
    Roders, P
    Hennink, WE
    [J]. JOURNAL OF CONTROLLED RELEASE, 1999, 60 (2-3) : 211 - 221
  • [9] A novel preparation method for polymeric microparticles without the use of organic solvents
    Franssen, O
    Hennink, WE
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 168 (01) : 1 - 7
  • [10] A synthetic mimic of the secretory granule for drug delivery
    Kiser, PF
    Wilson, G
    Needham, D
    [J]. NATURE, 1998, 394 (6692) : 459 - 462
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