Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: Case study

被引：45
作者：
Allen, JC
Judkins, AR
Rosenblum, MK
Biegel, JA
机构：
[1] Childrens Hosp Philadelphia, Abramson Res Ctr, Dept Pathol, Philadelphia, PA 19104 USA
[2] Childrens Hosp Philadelphia, Abramson Res Ctr, Dept Pediat, Philadelphia, PA 19104 USA
[3] NYU, Sch Med, Dept Neurol, New York, NY 10016 USA
[4] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
来源：
NEURO-ONCOLOGY | 2006年 / 8卷 / 01期
关键词：
atypical teratoid tumor; ganglioglioma; hSNF5/INI1; rhabdoid tumor;
D O I：
10.1215/S1522851705000347
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report an atypical teratoid/rhabdoid tumor arising in a ganglioglioma from an 11-year-old male who had been treated over a nine-year period. A combined histologic, immunohistochemical, and molecular genetic analysis confirmed this diagnosis. Molecular genetic studies demonstrated a mutation in exon 9 of the INI1 gene in the tumor, which was not present in the patient's blood. This report is the first to describe progression of a ganglioglioma to atypical teratoid/rhabdoid tumor.
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收藏
页码：79 / 82
页数：4
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