Original research association of one-point glucocorticoid-free status with chronic damage and disease duration in systemic lupus erythematosus: a cross-sectional study

被引：5

作者：

Sada, Ken-ei ^{[1
,2
]}

Katayama, Yu ^{[2
]}

Asano, Yosuke ^{[2
]}

Hayashi, Keigo ^{[2
]}

Miyawaki, Yoshia ^{[2
]}

Ohashi, Keiji ^{[2
]}

Katsuyama, Eri ^{[2
]}

Katsuyama, Takayuki ^{[2
]}

Takano-Narazaki, Mariko ^{[2
]}

Matsumoto, Yoshinori ^{[2
]}

Yoshimi, Ryusuke ^{[3
]}

Shimojima, Yasuhiro ^{[4
]}

Ohno, Shigeru ^{[5
]}

Kajiyama, Hiroshi ^{[6
]}

Ichinose, Kunihiro ^{[7
]}

Sato, Shuzo ^{[8
]}

Fujiwara, Michio ^{[9
]}

Yajima, Nobuyuki ^{[10
,11
,12
]}

机构：

[1] Kochi Med Sch, Dept Clin Epidemiol, Nanko Ku, Kochi, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Nephrol Rheumatol Endocrinol & Metab, Okayama, Japan

[3] Yokohama City Univ, Grad Sch Med, Dept Stem Cell & Immune Regulat, Yokohama, Kanagawa, Japan

[4] Shinshu Univ, Sch Med, Dept Med, Neurol & Rheumatol, Matsumoto, Nagano, Japan

[5] Yokohama City Univ, Med Ctr, Ctr Rheumat Dis, Yokohama, Kanagawa, Japan

[6] Saitama Med Univ, Fac Med, Dept Rheumatol & Appl Immunol, Saitama, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, Div Adv Prevent Med Sci, Dept Immunol & Rheumatol, Nagasaki, Japan

[8] Fukushima Med Univ, Sch Med, Dept Rheumatol, Fukushima, Japan

[9] Yokohama Rosai Hosp, Dept Rheumatol, Yokohama, Kanagawa, Japan

[10] Showa Univ, Sch Med, Dept Med, Div Rheumatol, Tokyo, Japan

[11] Fukushima Med Univ, Ctr Innovat Res Communities & Clin Excellence, Fukushima, Japan

[12] Kyoto Univ, Grad Sch Med, Sch Publ Hlth, Dept Healthcare Epidemiol, Kyoto, Japan

来源：

LUPUS SCIENCE & MEDICINE | 2022年 / 9卷 / 01期

关键词：

systemic lupus erythematosus; glucocorticoids; outcome assessment; health care; epidemiology; WITHDRAWAL; THERAPY; INDEX; VALIDATION; IMPACTS;

D O I：

10.1136/lupus-2022-000772

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective It is still unclear how glucocorticoids (GCs) affect the long-term clinical course of patients with SLE. The objective of this study is to explore the factors associated with GC-free treatment status. Methods Using data from the lupus registry of nationwide institutions, GC dose at registration was compared between short, middle and long disease durations of <5, 5-20 and >= 20 years, respectively. After excluding patients who never used GC, we evaluated the relationship between GC-free status and chronic damage using Systemic Lupus International Collaborating Clinics Damage Index. Results GC doses at enrolment of the 1019 patients were as follows: GC-free in 101 (10%); 0 Conclusion Even in the patients with long disease duration, one-point GC-free treatment status might be related to no chronic damage accrual.

引用

页数：6

共 43 条

[31] An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: a cross-sectional study [J].

Ravirajan, CT ;

Rowse, L ;

MacGowan, JR ;

Isenberg, DA .

RHEUMATOLOGY, 2001, 40 (12) :1405-1412

[32] Prevalence of vascular disease in systemic lupus erythematosus compared with type-1 diabetes mellitus: A cross-sectional study of two cohorts [J].

Koenig, K. F. ;

Ribi, C. ;

Radosavac, M. ;

Zulewski, H. ;

Trendelenburg, M. .

LUPUS, 2015, 24 (01) :58-65

[33] Dysregulated serum lipid profile and its correlation to disease activity in young female adults diagnosed with systemic lupus erythematosus: a cross-sectional study [J].

Zhou, Bo ;

Xia, Yulong ;

She, Jianqing .

LIPIDS IN HEALTH AND DISEASE, 2020, 19 (01)

[34] Dysregulated serum lipid profile and its correlation to disease activity in young female adults diagnosed with systemic lupus erythematosus: a cross-sectional study [J].

Bo Zhou ;

Yulong Xia ;

Jianqing She .

Lipids in Health and Disease, 19

[35] Association of Traditional Chinese Medicine Body Constitution and Health-Related Quality of Life in Female Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study [J].

Lai, Ning-Sheng ;

Lu, Ming-Chi ;

Chang, Hsiu-Hua ;

Lo, Hui-Chin ;

Hsu, Chia-Wen ;

Huang, Kuang-Yung ;

Tung, Chien-Hsueh ;

Hsu, Bao-Bao ;

Wu, Cheng-Han ;

Koo, Malcolm .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2021, 2021

[36] Health Care-Seeking Behaviors, Disease Progression, Medications, Knowledge of, and Attitudes Toward Systemic Lupus Erythematosus in China: Cross-sectional Survey Study [J].

Dai, Zonglin ;

Huang, Xinxiang ;

Yuan, Fei ;

Li, Tianwang ;

Xie, Baozhao ;

Lin, He ;

Yang, Pingting ;

Li, Xueyi ;

Xu, Shuiming ;

Zhao, Jinjun ;

Wang, Yukai ;

Peng, Xiang ;

Wei, Simin ;

Huang, Wei ;

Li, Jingyang ;

Liang, Jing ;

Liu, Xiuhua ;

Chu, Yongliang ;

Zhang, Zhiming ;

Zhang, Renpeng ;

Lau, Eric H. Y. ;

Lin, Zhiming .

JMIR PUBLIC HEALTH AND SURVEILLANCE, 2023, 9

[37] The mean platelet volume (MPV) in patients with systemic lupus erythematosus (SLE) and its correlation with disease activity: a cross-sectional/case-control study [J].

Khadra, Mariam ;

Drie, Tasneem S. ;

Kudsi, Maysoun .

ANNALS OF MEDICINE AND SURGERY, 2023, 85 (12) :5919-5925

[38] A comparative cross-sectional study of psychological distress, fatigue, and physical activity in patients with rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's disease [J].

Beider, Sonja ;

Stephan, Michael ;

Seeliger, Tabea ;

Skripuletz, Thomas ;

Witte, Torsten ;

Ernst, Diana .

FRONTIERS IN MEDICINE, 2025, 11

[39] The association between socioeconomic status and prevalence of chronic kidney disease: A cross-sectional study among rural residents in eastern China [J].

Shen, Quanquan ;

Jin, Wei ;

Ji, Shuiyu ;

Chen, Xiaoying ;

Zhao, Xiang ;

Behera, Tapas Ranjan .

MEDICINE, 2019, 98 (11)

[40] Cathelicidin (LL-37) and its correlation with pro-oxidant, antioxidant balance and disease activity in systemic lupus erythematosus: a cross-sectional human study [J].

Sahebari, M. ;

Roshandel, G. ;

Saadati, N. ;

Saghafi, M. ;

Abdolahi, N. ;

Rezaieyazdi, Z. .

LUPUS, 2017, 26 (09) :975-982

← 1 2 3 4 5 →