Original research association of one-point glucocorticoid-free status with chronic damage and disease duration in systemic lupus erythematosus: a cross-sectional study

被引：5

作者：

Sada, Ken-ei ^{[1
,2
]}

Katayama, Yu ^{[2
]}

Asano, Yosuke ^{[2
]}

Hayashi, Keigo ^{[2
]}

Miyawaki, Yoshia ^{[2
]}

Ohashi, Keiji ^{[2
]}

Katsuyama, Eri ^{[2
]}

Katsuyama, Takayuki ^{[2
]}

Takano-Narazaki, Mariko ^{[2
]}

Matsumoto, Yoshinori ^{[2
]}

Yoshimi, Ryusuke ^{[3
]}

Shimojima, Yasuhiro ^{[4
]}

Ohno, Shigeru ^{[5
]}

Kajiyama, Hiroshi ^{[6
]}

Ichinose, Kunihiro ^{[7
]}

Sato, Shuzo ^{[8
]}

Fujiwara, Michio ^{[9
]}

Yajima, Nobuyuki ^{[10
,11
,12
]}

机构：

[1] Kochi Med Sch, Dept Clin Epidemiol, Nanko Ku, Kochi, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Nephrol Rheumatol Endocrinol & Metab, Okayama, Japan

[3] Yokohama City Univ, Grad Sch Med, Dept Stem Cell & Immune Regulat, Yokohama, Kanagawa, Japan

[4] Shinshu Univ, Sch Med, Dept Med, Neurol & Rheumatol, Matsumoto, Nagano, Japan

[5] Yokohama City Univ, Med Ctr, Ctr Rheumat Dis, Yokohama, Kanagawa, Japan

[6] Saitama Med Univ, Fac Med, Dept Rheumatol & Appl Immunol, Saitama, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, Div Adv Prevent Med Sci, Dept Immunol & Rheumatol, Nagasaki, Japan

[8] Fukushima Med Univ, Sch Med, Dept Rheumatol, Fukushima, Japan

[9] Yokohama Rosai Hosp, Dept Rheumatol, Yokohama, Kanagawa, Japan

[10] Showa Univ, Sch Med, Dept Med, Div Rheumatol, Tokyo, Japan

[11] Fukushima Med Univ, Ctr Innovat Res Communities & Clin Excellence, Fukushima, Japan

[12] Kyoto Univ, Grad Sch Med, Sch Publ Hlth, Dept Healthcare Epidemiol, Kyoto, Japan

来源：

LUPUS SCIENCE & MEDICINE | 2022年 / 9卷 / 01期

关键词：

systemic lupus erythematosus; glucocorticoids; outcome assessment; health care; epidemiology; WITHDRAWAL; THERAPY; INDEX; VALIDATION; IMPACTS;

D O I：

10.1136/lupus-2022-000772

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective It is still unclear how glucocorticoids (GCs) affect the long-term clinical course of patients with SLE. The objective of this study is to explore the factors associated with GC-free treatment status. Methods Using data from the lupus registry of nationwide institutions, GC dose at registration was compared between short, middle and long disease durations of <5, 5-20 and >= 20 years, respectively. After excluding patients who never used GC, we evaluated the relationship between GC-free status and chronic damage using Systemic Lupus International Collaborating Clinics Damage Index. Results GC doses at enrolment of the 1019 patients were as follows: GC-free in 101 (10%); 0 Conclusion Even in the patients with long disease duration, one-point GC-free treatment status might be related to no chronic damage accrual.

引用

页数：6

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