Synthesis of Light-Responsive Pyrene-Based Polymer Nanoparticles via Polymerization-Induced Self-Assembly

被引:10
作者
Bagheri, Ali [1 ,2 ]
Boyer, Cyrille [2 ]
Lim, May [1 ]
机构
[1] Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia
[2] Univ New South Wales, Sch Chem Engn, Ctr NanoMed, Ctr Adv Macromol Design & Australian, Sydney, NSW 2052, Australia
关键词
RAFT DISPERSION POLYMERIZATION; COPOLYMER NANO-OBJECTS; BLOCK-COPOLYMER; BENZYL METHACRYLATE; PHOTO-PISA; EFFICIENT SYNTHESIS; CROSS-LINKING; DRUG; MICELLES; MORPHOLOGY;
D O I
10.1002/marc.201800510
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The use of an in situ, one-pot polymerization-induced self-assembly method to synthesize light-responsive pyrene-containing nanoparticles is reported. The strategy is based on the chain extension of a hydrophilic macromolecular chain transfer agent, poly(oligo(ethylene glycol) methyl ether methacrylate), using a light-responsive monomer, 1-pyrenemethyl methacrylate (PyMA), via a reversible addition-fragmentation chain transfer dispersion polymerization; yielding nanoparticles of various morphologies (spherical micelles and worm-like micelles). In this process, addition of comonomers, such as butyl methacrylate (BuMA) or methyl methacrylate (MMA), are required to obtain high PyMA monomer conversion (>80% in 24 h). The addition of comonomers reduces the pi-pi stacking of the pyrene moieties, which facilitates the diffusion of monomers in the nanoparticle core. The addition of BuMA (as a comonomer) offers P(PyMA-co-BuMA) core-forming chains with high mobility that enables the reorganization of chains and then the evolution of morphology to form vesicles. In contrast, when MMA comonomer is used, kinetically trapped spheres are obtained; this is due to the low mobility of the core-forming chains inhibiting in situ morphological evolution. Finally, the UV-light-induced dissociation of these light-responsive nanoparticles due to the gradual cleavage of the pyrene moieties and the subsequent hydrophobic-to-hydrophilic transitions of the core-forming blocks is demonstrated.
引用
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页数:7
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