FORMULATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF LORNOXICAM

被引：0
|
作者：
Kumar, P. Suresh [1 ]
Sravani, A. [1 ]
机构：
[1] Browns Coll Pharm, Dept Pharmaceut, Khammam 507305, Telangana, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2020年 / 11卷 / 06期
关键词：
Lornoxicam; Guar gum; Xanthan gum; Carbopol; 934; Controlled release tablets; DRUG-DELIVERY;
D O I：
10.13040/IJPSR.0975-8232.11(6).2793-00
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of the present study was to develop a controlled release formulation of Lornoxicam to maintain constant therapeutic levels of the drug for over 12 h. Guar gum, xantham gum, and carbopol 934 were employed as polymers. All the formulations were passed various physicochemical evaluation parameters, and they were found to be within limits. From the dissolution studies, it was evident that the formulation (F2) showed better and desired drug release patterns, i.e., 99.65% in 12 h. It contains the guar gum polymer. It followed the Higuchi order release kinetics mechanism.
引用
收藏
页码：2793 / 2800
页数：8
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