Home and clinic blood pressure responses in elderly individuals with systolic hypertension

Home blood pressure (BP) monitoring may enhance assessment of BP control. In this 16-week study, men and women 70 years or older with systolic BP between 150 and 200 mm Hg were randomized to receive valsartan/hydrochlorothiazide (V/HCTZ) 160/12.5 mg (n = 128), HCTZ 12.5 mg (n = 128), or V 160 mg (n = 128) for 4 weeks. Participants whose BP was 140/90 mm Hg or higher at weeks 4, 8, or 12 were uptitrated to a maximum of V/HCTZ 320/25 mg. Participants were evaluated by home BP monitoring using an automated device weekly before taking daily study medication (n = 301). Baseline BP +/- SD for clinic (165.5 +/- 11.8/85.1 +/- 9.5 mm Hg) was approximately 3/1 mm Hg greater than home readings (162.5 +/- 15.8/84.3 +/- 10.2 mm Hg). Reductions in BP +/- SEM at week 4 were similar for clinic (12.6 +/- 1.0/4.7 +/- 0.5 mm Hg) and home (10.9 +/- 1.1/3.8 +/- 0.5 mm Hg) readings (P = .25/P = .23; clinic versus home); differences between V/HCTZ and HCTZ or V were also similar for both home and clinic readings and results by either technique correlated significantly (P < .0001). Home BP measurements confirm that treatment initiated with V/HCTZ versus monotherapy resulted in greater antihypertensive efficacy. Home BP monitoring, if done with proper technique, provides a reliable indicator of BP control in elderly patients and may help guide drug dosing and titration. J Am Soc Hypertens 2012;6(3):210-218. (C) 2012 American Society of Hypertension. All rights reserved.