Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus

被引:65
|
作者
Shi, Dongyan [1 ]
Wang, Dandan [1 ]
Li, Xia [1 ]
Zhang, Huayong [1 ]
Che, Nan [2 ]
Lu, Zhimin [2 ]
Sun, Lingyun [1 ]
机构
[1] Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Immunol & Rheumatol, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Drum Tower Clin Med Coll, Dept Immunol & Rheumatol, Nanjing, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Diffuse alveolar hemorrhage; Mesenchymal stem cells; Systemic lupus erythematosus; Transplantation; INDUCED ACUTE LUNG; INTRAPULMONARY DELIVERY; PULMONARY HEMORRHAGE; MRL/LPR MICE; INJURY; RITUXIMAB; MULTIORGAN; THERAPY; PATIENT; BLOOD;
D O I
10.1007/s10067-012-1943-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Umbilical cord-derived mesenchymal stem cell transplantation (UC-MSCT) has been proved to be effective in the treatment of systemic lupus erythematosus (SLE), based on animal experiments and clinical trials. Diffuse alveolar hemorrhage (DAH) is a rare complication of SLE with a high mortality usually over 50%. This study aimed to assess the efficacy of UC-MSCT in the treatment of SLE-associated DAH. Four SLE patients complicated with DAH, who underwent UC-MSCT, were included. Clinical changes before and after transplantation were assessed by measurements of hemoglobin, platelet level, oxygen saturation, and serological factors. High-resolution CT (HRCT) scans of the chest were performed to evaluate pulmonary manifestation. All the four patients showed dramatic improvements of their clinical manifestations. Hemoglobin was elevated after UC-MSCT and was sustained at a normal level 6 months after UC-MSCT in the four patients. Platelet level was upregulated in two patients who had thrombocytopenia at baseline. Oxygen saturation appeared to be normal at 1 month after UC-MSCT, and this result was confirmed by the HRCT scan of the chest. Serum albumin elevated to 3.5 g/dl 6 months after transplantation. Our findings suggest that UC-MSCT results in amelioration of oxygen saturation as well as hematological and serologic changes, which revealed that UC-MSCT could be applied as a salvage strategy for DAH patients.
引用
收藏
页码:841 / 846
页数:6
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