Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation

被引：25

作者：

Liu, Jia-Wang ^{[1
,4
]}

Zhang, Min-Yu ^{[2
]}

Yan, Yong-Min ^{[2
]}

Wei, Xiao-Yi ^{[5
]}

Dong, Lu ^{[1
]}

Zhu, Yan-Xia ^{[2
]}

Cheng, Yong-Xian ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Sch Pharmaceut Sci,Hlth Sci Ctr, Shenzhen Key Lab Antiaging & Regenerat Med,Dept C, Shenzhen 518060, Peoples R China

[3] Henan Univ Chinese Med, Zhengzhou 450008, Henan, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 05期

关键词：

ZETA VALENCE QUALITY; BASIS-SETS; THERMOCHEMISTRY; MYRRH;

D O I：

10.1021/acs.joc.7b03182

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new sesquiterpene dimers commiphoroids A-D (1-4) were isolated from Resina Commiphora, and their structures were assigned by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 2 are stereoisomers of putative [2 + 4]-cycloaddition reactions, and 3 is a trinorsesquiterpene dimer containing a 6/6/5/6/6/6 hexacyclic framework, while 4 possesses a 8-oxabicyclo[3.2.1]oct-6-ene skeletal core. Plausible biosynthetic pathways for 1-4 are proposed. Biochemical studies show that compound 1 promotes ca. 60% expression of keratinocyte-specific markers in adipose derived stem cells at 10 mu M.

引用

页码：2725 / 2733

页数：9

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