Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation

被引：25
|
作者：
Liu, Jia-Wang [1 ,4 ]
Zhang, Min-Yu [2 ]
Yan, Yong-Min [2 ]
Wei, Xiao-Yi [5 ]
Dong, Lu [1 ]
Zhu, Yan-Xia [2 ]
Cheng, Yong-Xian [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[2] Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Sch Pharmaceut Sci,Hlth Sci Ctr, Shenzhen Key Lab Antiaging & Regenerat Med,Dept C, Shenzhen 518060, Peoples R China
[3] Henan Univ Chinese Med, Zhengzhou 450008, Henan, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[5] South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 05期
关键词：
ZETA VALENCE QUALITY; BASIS-SETS; THERMOCHEMISTRY; MYRRH;
D O I：
10.1021/acs.joc.7b03182
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The new sesquiterpene dimers commiphoroids A-D (1-4) were isolated from Resina Commiphora, and their structures were assigned by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 2 are stereoisomers of putative [2 + 4]-cycloaddition reactions, and 3 is a trinorsesquiterpene dimer containing a 6/6/5/6/6/6 hexacyclic framework, while 4 possesses a 8-oxabicyclo[3.2.1]oct-6-ene skeletal core. Plausible biosynthetic pathways for 1-4 are proposed. Biochemical studies show that compound 1 promotes ca. 60% expression of keratinocyte-specific markers in adipose derived stem cells at 10 mu M.
引用
收藏
页码：2725 / 2733
页数：9
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