Bifunctional aryloxyphosphoramidate prodrugs of 2′-C-Me-uridine: synthesis and anti-HCV activity

被引：4

作者：

Maiti, Munmun ^{[1
]}

Gao, Ling-Jie ^{[1
]}

Huang, Chunsheng ^{[2
]}

Ptak, Roger G. ^{[2
]}

Murray, Michael G. ^{[2
]}

De Jonghe, Steven ^{[1
]}

Herdewijn, Piet ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst, Med Chem Lab, Minderbroedersstr 10, B-3000 Leuven, Belgium

[2] Southern Res, Infect Dis Res, 431 Aviat Way, Frederick, MD 21701 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 37期

基金：

美国国家卫生研究院;

关键词：

HEPATITIS-C VIRUS; ARYLOXY PHOSPHORAMIDATE TRIESTERS; NUCLEOSIDE PHOSPHATE; AMINO-ACID; REPLICATION; TECHNOLOGY; INHIBITORS; CANCER; CELLS;

D O I：

10.1039/c6ob01189f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of L-glutamic acid, L-serine, L-threonine and L-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they displayed very potent anti-HCV activity, with EC50 values that are in the same range as of Sofosbuvir.

引用

页码：8743 / 8757

页数：15

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