Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives

被引：19

作者：

Salehi, Peyman ^{[2
]}

MaGee, David I. ^{[1
]}

Dabiri, Minoo ^{[3
]}

Torkian, Laleh ^{[3
]}

Donahue, Jordan ^{[1
]}

机构：

[1] Univ New Brunswick, Dept Chem, Fredericton, NB E3B 5A3, Canada

[2] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, GC, Tehran 1983963113, Iran

[3] Shahid Beheshti Univ, Dept Chem, Fac Sci, GC, Tehran 1983963113, Iran

来源：

MOLECULAR DIVERSITY | 2012年 / 16卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Click chemistry; 1,2,3-Triazole; One-pot reaction; Multicomponent reaction; MCR; Phthalhydrazide; EFFICIENT ONE-POT; AZIDE CYCLOADDITION REACTIONS; SILICA SULFURIC-ACID; CHEMISTRY; 3-COMPONENT; PHTHALAZINE; DISCOVERY; CATALYST; WATER;

D O I：

10.1007/s11030-011-9348-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

引用

页码：231 / 240

页数：10

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