Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents

被引：106

作者：

Abdel-Wahab, Bakr F. ^{[1
]}

Abdel-Latif, Ehab ^{[2
]}

Mohamed, Hanan A. ^{[1
]}

Awad, Ghada E. A.

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt

[2] Mansoura Univ, Dept Chem, Fac Sci, ET-35516 Mansoura, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 52卷

关键词：

Pyrazolyltriazole; Biheterocycles; Antimicrobial; X-ray crystallography;

D O I：

10.1016/j.ejmech.2012.03.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New pyrazolyl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolylthiazoles were synthesized through multi step reactions using 1-tolylyl-4-acetyl-5-methyl-1,2,3-triazole as a precursor. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of lib was evidenced by X-ray crystallographic study. The newly synthesized compounds were evaluated for their antimicrobial activities and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested compounds 5a, 5c, 11b and 11c displayed excellent antimicrobial activity. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：263 / 268

页数：6

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