A Translational View of Biomarkers in Preterm Labor

被引：8

作者：

Hanna, Nazeeh ^{[1
]}

Kiefer, Daniel ^{[2
]}

机构：

[1] Winthrop Univ Hosp, Div Neonatol, Women & Childrens Res Lab, Mineola, NY 11501 USA

[2] Lehigh Valley Hlth Network, Div Maternal Fetal Med Obstet & Gynecol, Allentown, PA USA

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2012年 / 67卷 / 04期

关键词：

Biomarkers; cytokines; inflammation; intrauterine compartments; non-invasive sampling; preterm labor; AMNIOTIC-FLUID; SHORT CERVIX; CERCLAGE; ULTRASOUND; EXPRESSION; LENGTH; RISK;

D O I：

10.1111/j.1600-0897.2012.01112.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Preterm labor and birth continue to pose a significant challenge to physicians in the obstetrics and neonatal fields. Until specific and effective therapeutic treatments are developed to prevent preterm labor, the best means of reducing preterm birth rate is early detection and diagnosis. However, current approaches to predict preterm labor have had variable success in the clinical setting. In this review, we discuss several limitations of using biomarkers from biological samples to predict preterm labor. In addition, we propose strategies for improving our ability to predict preterm labor, as well as directing therapies that are best suited to the underlying cause of preterm labor.

引用

页码：268 / 272

页数：5

共 19 条

[1] Cerclage for short cervix on ultrasonography - Meta-analysis of trials using individual patient-level data [J].

Berghella, V ;

Odibo, AO ;

To, MS ;

Rust, OA ;

Althuisius, SM .

OBSTETRICS AND GYNECOLOGY, 2005, 106 (01) :181-189

[2] Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection [J].

Chow, Sharon S. W. ;

Craig, Maria E. ;

Jones, Cheryl A. ;

Hall, Beverley ;

Catteau, Jacki ;

Lloyd, Andrew R. ;

Rawlinson, William D. .

CYTOKINE, 2008, 44 (01) :78-84

[3] Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor [J].

Esplin, MS ;

Peltier, MR ;

Hamblin, S ;

Smith, S ;

Fausett, MB ;

Dildy, GA ;

Branch, DW ;

Silver, RM ;

Adashi, EY .

PLACENTA, 2005, 26 (8-9) :661-671

[4] Evidence for interleukin-10-mediated inhibition of cyclo-oxygenase-2 expression and prostaglandin production in preterm human placenta [J].

Hanna, N ;

Bonifacio, L ;

Weinberger, B ;

Reddy, P ;

Murphy, S ;

Romero, R ;

Sharma, S .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2006, 55 (01) :19-27

[5] CERVICAL COMPETENCE AS A CONTINUUM - A STUDY OF ULTRASONOGRAPHIC CERVICAL LENGTH AND OBSTETRIC PERFORMANCE [J].

IAMS, JD ;

JOHNSON, FF ;

SONEK, J ;

SACHS, L ;

GEBAUER, C ;

SAMUELS, P .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 172 (04) :1097-1106

[6] The length of the cervix and the risk of spontaneous premature delivery [J].

Iams, JD ;

Goldenberg, RL ;

Meis, PJ ;

Mercer, BM ;

Moawad, A ;

Das, A ;

Thom, E ;

McNellis, D ;

Copper, RL ;

Johnson, F ;

Roberts, JM ;

Hauth, JC ;

Northern, A ;

Neely, C ;

MuellerHeubach, E ;

Swain, M ;

Frye, A ;

Lindheimer, M ;

Jones, P ;

Brown, MEL ;

Siddiqi, TA ;

Elder, N ;

Coombs, T ;

VanHorn, J ;

Bain, R ;

Leuchtenburg, L ;

Fischer, M ;

Harger, JH ;

Cotroneo, M ;

Stallings, C ;

Yaffe, S ;

Catz, C ;

Klebanoff, M ;

Landon, MB ;

Schneider, J ;

Mueller, C ;

Carey, JC ;

Meier, A ;

Liles, E ;

Newman, RB ;

Collins, BA ;

Metcalf, T ;

Odell, V ;

Sibai, B ;

Ramsey, R ;

Fricke, JL ;

Treadwell, M ;

Norman, GS .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (09) :567-572

[7] Comprehensive amniotic fluid cytokine profile evaluation in women with a short cervix: which cytokine(s) correlates best with outcome? [J].

Keeler, Sean M. ;

Kiefer, Daniel G. ;

Rust, Orion A. ;

Vintzileos, Anthony ;

Atlas, Robert O. ;

Bornstein, Eran ;

Hanna, Nazeeh .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2009, 201 (03) :276.e1-276.e6

[8]

Kiefer D, 2011, AM J OBSTET GYNECOL, V204, P90

[9] Amniotic fluid inflammatory score is associated with pregnancy outcome in patients with mid trimester short cervix [J].

Kiefer, Daniel G. ;

Keeler, Sean M. ;

Rust, Orion ;

Chow, Sharon S. W. ;

Craig, Maria E. ;

Peltier, Morgan R. ;

Vintzileos, Anthony M. ;

Rawlinson, William D. ;

Hanna, Nazeeh .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2012, 206 (01) :68.e1-68.e6

[10] Is midtrimester short cervix a sign of intraamniotic inflammation? [J].

Kiefer, Daniel G. ;

Keeler, Sean M. ;

Rust, Orion A. ;

Wayock, Christopher P. ;

Vintzileos, Anthony M. ;

Hanna, Nazeeh .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2009, 200 (04) :374.e1-374.e5

← 1 2 →