Hypotension from afatinib in epidermal growth factor receptor-mutated non-small cell lung cancer: a case report and literature review

被引：2
|
作者：
Tang, Zhiwei [1 ]
Ji, XiuHai [2 ]
Zhou, Guanghui [1 ]
Chen, Ruhua [1 ]
Fen, Yan [1 ]
Ding, Hui [1 ]
机构：
[1] Jiangsu Univ, Affiliated Yixing Peoples Hosp, Dept Pulm & Crit Care Med, Yixing, Peoples R China
[2] Affiliated Taicang Hosp Tradit Chinese Med, Dept Oncol, Taicang, Peoples R China
来源：
ANTI-CANCER DRUGS | 2022年 / 33卷 / 01期
关键词：
afatinib; epidermal growth factor receptor; hypotension; lung cancer;
D O I：
10.1097/CAD.0000000000001244
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Side effects of afatinib are a problem in patients with advanced non-small cell lung cancer (NSCLC). However, little is known about the occurrence of afatinib-induced hypotension. An 81-year-old man with NSCLC had an epidermal growth factor receptor-positive genotype with the p.L861Q mutation in exon 21. He was administered afatinib (40 mg/day) as anticancer therapy. Hypotension occurred twice after afatinib initiation. He suffered from dizziness and nausea. Blood pressure gradually returned to normal after afatinib cessation. Clinicians should be aware of hypotension in patients with NSCLC after afatinib initiation.
引用
收藏
页码：E840 / E841
页数：2
相关论文
共 50 条
  • [41] Cost of early progression: patients with epidermal growth factor receptor mutated metastatic non-small-cell lung cancer
    Nicole, Princic
    Elizabeth, Marrett
    Jacqueline, Kwong Winghan
    Donna, Mcmorrow
    Hana, Schwartz
    Janakiraman, Subramanian
    FUTURE ONCOLOGY, 2024, 20 (24) : 1753 - 1764
  • [42] Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in mutated non-small cell lung cancer: new avenues and strategies to overcome resistance
    Absenger, Gudrun
    MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY, 2019, 12 (02) : 128 - 135
  • [43] Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-Small Cell Lung Cancer: A Review
    Karlsen, Emma-Anne
    Kahler, Sam
    Tefay, Joan
    Joseph, Shannon R.
    Simpson, Fiona
    CELLS, 2021, 10 (05)
  • [44] Front-line therapy for brain metastases and non-brain metastases in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: a network meta-analysis
    Zhu, Yixiang
    Liu, Chengcheng
    Xu, Ziyi
    Zou, Zihua
    Xie, Tongji
    Xing, Puyuan
    Wang, Le
    Li, Junling
    CHINESE MEDICAL JOURNAL, 2023, 136 (21) : 2551 - 2561
  • [45] Afatinib in the first-line treatment of epidermal-growth-factor-receptor mutation-positive non-small cell lung cancer: a review of the clinical evidence
    Ke, E-E
    Wu, Yi-Long
    THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, 2016, 10 (03) : 256 - 264
  • [46] High rate of epidermal growth factor receptor-mutated primary lung cancer in patients with primary breast cancer
    Zeng, Tianyu
    Xu, Hai
    Liu, Yincheng
    Sun, Chunxiao
    Yang, Fan
    Liang, Yan
    Huang, Xiang
    Fu, Ziyi
    Li, Wei
    Yin, Yongmei
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [47] Optimizing the Treatment for Advanced Non-Small-Cell Lung Cancer with Mutated Epidermal Growth Factor Receptor in Low-Income Countries: A Review
    Alali, Mousa
    Saifo, Maher
    JOURNAL OF IMMUNOTHERAPY AND PRECISION ONCOLOGY, 2023, 6 (03) : 140 - 149
  • [48] Front-line therapy for brain metastases and non-brain metastases in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: a network meta-analysis
    Zhu Yixiang
    Liu Chengcheng
    Xu Ziyi
    Zou Zihua
    Xie Tongji
    Xing Puyuan
    Wang Le
    Li Junling
    中华医学杂志英文版, 2023, 136 (21)
  • [49] New prognostic system specific for epidermal growth factor receptor-mutated lung cancer brain metastasis
    Zhu, Li-Hua
    Fan, Xing-Wen
    Sun, Lu
    Ni, Ting-ting
    Li, Ya-qi
    Wu, Chao-Yang
    Wu, Kai-Liang
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [50] First-Line Afatinib versus Chemotherapy in Patients with Non-Small Cell Lung Cancer and Common Epidermal Growth Factor Receptor Gene Mutations and Brain Metastases
    Schuler, Martin
    Wu, Yi-Long
    Hirsh, Vera
    O'Byrne, Kenneth
    Yamamoto, Nobuyuki
    Mok, Tony
    Popat, Sanjay
    Sequist, Lecia V.
    Massey, Dan
    Zazulina, Victoria
    Yang, James C. -H.
    JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (03) : 380 - 390
12345