Combined immunoradiotherapy induces long-term remission of CNS relapse of peripheral, diffuse, large-cell lymphoma after allogeneic stem cell transplantation:: Case study

被引:6
作者
Lotze, C
Schüler, F
Krüger, WH
Hirt, C
Kirsch, M
Vogelgesang, S
Schmidt, CA
Dölken, G
机构
[1] Univ Greifswald, Internal Med C Hematol & Oncol Transplant Ctr, D-17487 Greifswald, Germany
[2] Univ Greifswald, Inst Pathol, D-17487 Greifswald, Germany
关键词
non-Hodgkin's lymphoma; allogeneic stem cell transplantation; graft-versus-lymphoma effect; anti-CD20; antibodies;
D O I
10.1215/S1152851705000256
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Relapse of peripheral non-Hodgkin's lymphoma (NHL) in the central nervous system commonly has a poor prognosis. Graft-versus-leukemia effects (GvL) contribute substantially to eradication of hematological malignancies after allogeneic stem cell transplantation. Few data are available describing GvL activity within the brain. We report the case of a man allografted for peripheral NHL. On day +83 after transplantation a CNS relapse of the lymphoma occurred. The brain was irradiated with 44 Gy, anti-CD20 antibodies were given, and the immunosuppression was withdrawn. Subsequently, limited-stage, chronic graft-versus-host disease occurred. The lymphoma regressed completely, and the patient has been in continuous complete remission for 30 months. The favorable course suggests substantial contribution of immunomodulation to excellent outcome.
引用
收藏
页码:508 / 510
页数:3
相关论文
共 8 条
[1]   Treosulfan and fludarabine:: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation [J].
Casper, J ;
Knauf, W ;
Kiefer, T ;
Wolff, D ;
Steiner, B ;
Hammer, U ;
Wegener, R ;
Kleine, HD ;
Wilhelm, S ;
Knopp, A ;
Hartung, G ;
Dölken, G ;
Freund, M .
BLOOD, 2004, 103 (02) :725-731
[2]   Long-term remission of APL with a second allogeneic BMT after CNS relapse following HLA-identical allogeneic BMT [J].
Classen, CF ;
Debatin, KM ;
Friedrich, W ;
Schulz, AS .
BONE MARROW TRANSPLANTATION, 2003, 32 (08) :843-846
[3]  
Curtis RE, 1999, BLOOD, V94, P2208
[4]   Detection of minimal residual disease [J].
Dölken, G .
ADVANCES IN CANCER RESEARCH, VOL 82, 2001, 82 :133-185
[5]   Chimerism analysis on mononuclear cells in the CSF after allogeneic bone marrow transplantation [J].
Hibi, S ;
Tsunamoto, K ;
Todo, S ;
Sawada, T ;
Ueda, Y ;
Taniwaki, M ;
Naya, M ;
Hojo, M ;
Imashuku, S .
BONE MARROW TRANSPLANTATION, 1997, 20 (06) :503-506
[6]   DONOR LEUKOCYTE TRANSFUSIONS FOR TREATMENT OF RECURRENT CHRONIC MYELOGENOUS LEUKEMIA IN MARROW TRANSPLANT PATIENTS [J].
KOLB, HJ ;
MITTERMULLER, J ;
CLEMM, C ;
HOLLER, E ;
LEDDEROSE, G ;
BREHM, G ;
HEIM, M ;
WILMANNS, W .
BLOOD, 1990, 76 (12) :2462-2465
[7]   Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma [J].
van Besien, K ;
Ha, CS ;
Murphy, S ;
McLaughlin, P ;
Rodriguez, A ;
Amin, K ;
Forman, A ;
Romaguera, J ;
Hagemeister, F ;
Younes, A ;
Bachier, C ;
Sarris, A ;
Sobocinski, KS ;
Cox, JD ;
Cabanillas, F .
BLOOD, 1998, 91 (04) :1178-1184
[8]   Graft-versus-lymphoma effect after allogeneic peripheral blood stem cell transplantation for primary central nervous system lymphoma [J].
Varadi, G ;
Or, R ;
Kapelushnik, J ;
Naparstek, E ;
Nagler, A ;
Brautbar, C ;
Amar, A ;
Kirschbaum, M ;
Samuel, S ;
Slavin, S ;
Siegal, T .
LEUKEMIA & LYMPHOMA, 1999, 34 (1-2) :185-190