Cardioactive C19-Diterpenoid Alkaloids from the Lateral Roots of Aconitum carmichaeli "Fu Zi"

被引：88
|
作者：
Liu, Xiu-Xiu [1 ]
Jian, Xi-Xian [2 ]
Cai, Xiu-Feng [1 ]
Chao, Ruo-Bing [1 ]
Chen, Qiao-Hong [2 ]
Chen, Dong-Lin [2 ]
Wang, Xiao-Liang [3 ]
Wang, Feng-Peng [1 ,2 ]
机构：
[1] Sichuan Univ, W China Coll Pharm, Dept Med Anal, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Coll Pharm, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2012年 / 60卷 / 01期
关键词：
Aconitum carmichaeli; cardioactive constituent; Fu Zi; N-deethylaconine; beiwutinine; IONIZATION MASS-SPECTROMETRY; LIPO-ALKALOIDS; C-20-DITERPENOID ALKALOIDS; NORDITERPENOID ALKALOIDS; DITERPENIC ALKALOIDS; PROCESSED TUBERS; DEBX; COMPONENTS; PRINCIPLE;
D O I：
10.1248/cpb.60.144
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bioassay-guided fractionation of an n-BuOH extract of the lateral roots of Aconitum carmichaeli DEUX. led to the isolation of 5 cardioactive C-19-diterpenoid alkaloids: N-deethylaconine (1), beiwutinine (2), hypaconine (3), mesaconine (4), and 15 alpha-hydroxyneoline (5). N-Deethylaconine and beiwutinine are new aconitine-type C-19-diterpenoid alkaloids. Hypaconine was isolated from this species for the first time. Among them, mesaconine, hypaconine, and beiwutinine showed the strongest cardiac actions on the isolated perfused bullfrog heart. Furthermore, mesaconine has protective effects, including improved inotropic effect and left ventricular diastolic function, on myocardial ischemia-reperfusion injury in rat at a dose of 10(-9) mol/L. However, mesaconine has almost no effect on heart rate.
引用
收藏
页码：144 / 149
页数：6
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