Quantitative structure activity relationship (QSAR) studies on sulphide analogues as potent M2 muscarinic receptor antagonists

被引：0
|
作者：
Srivastava, AK [1 ]
Khan, AA [1 ]
Tripathi, A [1 ]
Archana [1 ]
机构：
[1] Univ Allahabad, Dept Chem, Allahabad 211002, Uttar Pradesh, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2005年 / 82卷 / 09期
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D O I：
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中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
QSAR studies on sulphide analogues (1-12) of M-2 muscarinic receptor antagonists for the treatment of cognitive disorder are reported. The activity of compound 1(1-naphthyl) is found to be most potent analogue of the series as shown by electronic, hydrophobic and steric factors.
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页码：850 / 852
页数：3
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