Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis

被引：8

作者：

Yu, Jiangfan ^{[1
]}

Tang, Rui ^{[2
]}

Ding, Ke ^{[3
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410011, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Rheumatol & Immunol, Changsha 410011, Peoples R China

[3] Cent South Univ, Xiangya Hosp, Dept Urol, Changsha 410008, Peoples R China

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2022年 / 15卷

基金：

中国国家自然科学基金;

关键词：

systemic sclerosis; pathogenesis; epigenetics; biomarkers; DERMAL FIBROBLASTS; COLLAGEN EXPRESSION; DNA METHYLATION; GENE-EXPRESSION; EMERGING ROLE; SCLERODERMA; HISTONE; INTERFERON; CELLS; ACTIVATION;

D O I：

10.2147/IJGM.S356877

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic sclerosis is a rare chronic autoimmune disease, which mainly manifests as immune disorders, vascular damage, and progressive fibrosis. The etiology of SSc is complex and involves multiple factors. Both genetic and environmental factors are involved in its pathogenesis. As one of the molecular mechanisms of environmental factors, epigenetic regulation plays an important role in the occurrence and development of systemic sclerosis, which involves DNA methylation, histone modification and non-coding RNA regulation. This review summarizes research advances in epigenetics, including exosomes, lncRNA, and mentions possible biomarkers and therapeutic targets among them.

引用

页码：3155 / 3166

页数：12

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