An efficient synthesis of highly functionalized novel chromeno[4,3-b]pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents

被引：66

作者：

Arumugam, Natarajan ^{[1
]}

Raghunathan, Raghavachary ^{[2
]}

Almansour, Abdulrahman I. ^{[1
]}

Karama, Usama ^{[1
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

[2] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 03期

关键词：

Azomethine ylide; 1,3-DC reaction; Pictet-Spengler cyclization; Chromenopyrroles; Indolizinoindoles; Antimicrobial activity; 1,3-DIPOLAR CYCLOADDITION REACTION; RECEPTOR ANTAGONISTS; ORGANIC-SYNTHESIS; DERIVATIVES; RESISTANCE; PRODUCTS; ACID;

D O I：

10.1016/j.bmcl.2011.12.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A facile and efficient synthesis of novel chromeno[4,3-b]pyrroles has been accomplished by intramolecular 1,3-dipolar cycloaddition which on subsequent Pictet-Spengler cyclisation in presence of p-toluenesulfonic acid yielded indolizino[6,7-b]indoles. The synthesized chromenopyrroles and indolizinoindoles were evaluated for their antimicrobial and antioxidant activities. Compounds 7b, 7e, 7a and 7d exhibited respectively, good antibacterial and antifungal activities against tested pathogens when compared to reference control. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1375 / 1379

页数：5

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