Trifluoromethylation of heterocycles via visible light photoredox catalysis

被引：189
|
作者：
Iqbal, Naeem [1 ]
Choi, Sungkyu [1 ]
Ko, Euna [1 ]
Cho, Eun Jin [1 ]
机构：
[1] Hanyang Univ, Dept Chem & Appl Chem, Ansan 426791, Kyeonggi Do, South Korea
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 15期
基金：
新加坡国家研究基金会;
关键词：
Visible light; Photoredox catalysis; Trifluoromethylation; Heterocycles; Ruthenium; C-H FUNCTIONALIZATION; OXIDATIVE TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; MEDICINAL CHEMISTRY; BORONIC ACIDS; ARYL; PHOTOCATALYSIS; FLUORINATION; BOND; CYCLOADDITIONS;
D O I：
10.1016/j.tetlet.2012.02.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method has been developed for the visible light-induced trifluoromethylation of heterocyclic compounds. A variety of electron-rich heterocycles were transformed into trifluoromethylated products by using CF3I as the trifluoromethyl radical source and Ru(bpy)(3)Cl-2 as the photocatalyst under mild reaction conditions. This operationally simple and eco-friendly process can introduce trifluoromethyl groups without prefunctionalization. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2005 / 2008
页数：4
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