For MutY, It's All about the OG

被引：7

作者：

Sobol, Robert W. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Dept Human Genet, Grad Sch Publ Hlth, Pittsburgh, PA 15213 USA

来源：

CHEMISTRY & BIOLOGY | 2012年 / 19卷 / 03期

关键词：

BASE-EXCISION-REPAIR; DNA-DAMAGE; CANCER;

D O I：

10.1016/j.chembiol.2012.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine. In a recent issue of Chemistry & Biology, Brinkmeyer et al. utilized mutant forms of MutY to reveal the critical residues in MutY that are required for this selectivity and specificity.

引用

页码：313 / 314

页数：2