Structure, Mechanics, and Histology of Intraluminal Thrombi in Abdominal Aortic Aneurysms

被引:33
作者
Tong, Jianhua [1 ]
Holzapfel, Gerhard A. [2 ]
机构
[1] Tongji Univ, Sch Med, Shanghai East Hosp, Inst Biomed Engn & Nano Sci, Shanghai 200092, Peoples R China
[2] Graz Univ Technol, Inst Biomech, A-8010 Graz, Austria
关键词
Intraluminal thrombus; Abdominal aortic aneurysm; Structure; Biomechanics; Morphology; Histology; PATIENT-SPECIFIC MODELS; COVERED WALL; VISCOELASTIC BEHAVIOR; RUPTURE; FIBRIN; AGE; HEMODYNAMICS; STRESS; BIOMECHANICS; DEPOSITION;
D O I
10.1007/s10439-015-1332-5
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
It has been recognized that the intraluminal thrombus (ILT) is a biologically active material contributing in the progression and rupture of abdominal aortic aneurysms (AAAs). To advance our understanding of the potential role of ILT in the natural history of AAAs, the structural, mechanical, and histological characteristics of ILTs have been studied with great interest over the past decade. Given that the ILT is evolving and changing its composition during AAA progression, attention has been paid to exploring the chemomechanical effects of ILT on the underlying wall properties. Various biomechanical and chemomechanical data, and related models have provided advanced insights into AAA pathogenesis which have served as a basis for clinical diagnosis. The goal of this review is to describe and summarize recent advances in the research of ILT found in the aorta in terms of structure, mechanics, and histology on a patient-specific basis. We point to some possible future studies which hopefully stimulate multidisciplinary research to address open problems.
引用
收藏
页码:1488 / 1501
页数:14
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