Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury

被引：28

作者：

Fujiki, Minoru ^{[1
]}

Kubo, Takeshi ^{[1
]}

Kamida, Tohru ^{[1
]}

Sugita, Kenji ^{[1
]}

Hikawa, Takamitsu ^{[1
]}

Abe, Tatsuya ^{[1
]}

Ishii, Keisuke ^{[1
]}

Kobayashi, Hidenori ^{[1
]}

机构：

[1] Oita Univ, Sch Med, Dept Neurosurg, Oita 87011, Japan

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2008年 / 15卷 / 07期

关键词：

donepezil; mild traumatic brain injury; concussion; neuronal death; memory impairment; neuroprotection;

D O I：

10.1016/j.jocn.2007.07.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study we evaluated the effect of donepezil on the neurodegeneration and behavioral impairments induced by mild traumatic brain injury (MTBI). Donepezil is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease. Donepezil was given orally to rats subjected to MTBI. Treatment with a single oral dose of donepezil (12 mg/kg) immediately after injury significantly attenuated MTBI-induced neuronal death and cognitive impairment as measured by preservation of neurons in the CA1 region of the hippocampus and a water maze test respectively. However, these neuroprotective effects were prevented by concomitant injection of mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection is mediated by nAChR activation. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：791 / 796

页数：6

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