Try Me: Promiscuous Inhibitors Still Allow for Selective Targeted Protein Degradation

被引：7
作者：
Muller, Matthias P. [1 ]
Rauh, Daniel [1 ]
机构：
[1] Tech Univ Dortmund, Fac Chem & Chem Biol, Otto Hahn Str 4a, D-44227 Dortmund, Germany
来源：
CELL CHEMICAL BIOLOGY | 2018年 / 25卷 / 01期
关键词：
KINASES; PROTACS;
D O I：
10.1016/j.chembiol.2018.01.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Cell Chemical Biology, Bondeson et al. (2018), Burslem et al. (2018), and Huang et al. (2018) systematically characterize proteolysis-targeting chimeras (PROTACs) regarding their specificity and general advantages of targeted proteolysis of cellular proteins and provide interesting insights into possible future developments.
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收藏
页码：4 / 6
页数：3
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