Dendritic cells in tissues: in situ stimulation of immunity and immunopathology

被引：17

作者：

Bennett, Clare L. ^{[1
]}

Chakraverty, Ronjon ^{[1
]}

机构：

[1] Dept Haematol, Div Canc Studies, London NW3 2PF, England

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 01期

关键词：

REGULATORY T-CELLS; INFLUENZA-VIRUS; LYMPH-NODES; B-CELLS; EFFECTOR; ACTIVATION; MIGRATION; RESPONSES; MACROPHAGES; HOMEOSTASIS;

D O I：

10.1016/j.it.2011.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) prime and orchestrate naive T cell immunity in lymphoid organs, but recent data also highlight the importance of DC-effector T cell interactions in tissues. These studies suggest that effector T cells require a second activating step in situ from tissue DCs to become fully competent for effector functions and/or proliferation and survival. DC stimulation of effector T cells within tissues has evolved as a mechanism to ensure that T cells are activated to their full potential only at the site of ongoing infection. Here, we propose that under conditions of uncontrolled inflammation and release of tissue antigens, the same DC-dependent checkpoint perpetuates a destructive response and immunopathology.

引用

页码：8 / 13

页数：6

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