Role of Dietary Lipids in Modulating Inflammation through the Gut Microbiota
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作者:
Wisniewski, Paul J.
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机构:Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Dept Kinesiol & Hlth, New Brunswick, NJ 08901 USA
Wisniewski, Paul J.
Dowden, Robert A.
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机构:Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Dept Kinesiol & Hlth, New Brunswick, NJ 08901 USA
Dowden, Robert A.
Campbell, Sara C.
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Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Dept Kinesiol & Hlth, New Brunswick, NJ 08901 USARutgers State Univ, New Jersey Inst Food Nutr & Hlth, Dept Kinesiol & Hlth, New Brunswick, NJ 08901 USA
Campbell, Sara C.
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机构:
[1] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Dept Kinesiol & Hlth, New Brunswick, NJ 08901 USA
Inflammation and its resolution is a tenuous balance that is under constant contest. Though several regulatory mechanisms are employed to maintain homeostasis, disruptions in the regulation of inflammation can lead to detrimental effects for the host. Of note, the gut and microbial dysbiosis are implicated in the pathology of systemic chronic low-grade inflammation which has been linked to several metabolic diseases. What remains to be described is the extent to which dietary fat and concomitant changes in the gut microbiota contribute to, or arise from, the onset of metabolic disorders. The present review will highlight the role of microorganisms in host energy regulation and several mechanisms that contribute to inflammatory pathways. This review will also discuss the immunomodulatory effects of the endocannabinoid system and its link with the gut microbiota. Finally, a brief discussion arguing for improved taxonomic resolution (at the species and strain level) is needed to deepen our current knowledge of the microbiota and host inflammatory state.
机构:
UNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELANDUNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELAND
Benzie, IFF
Strain, JJ
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UNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELANDUNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELAND
机构:
UNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELANDUNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELAND
Benzie, IFF
Strain, JJ
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h-index: 0
机构:
UNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELANDUNIV ULSTER, HUMAN NUTR RES GRP, COLERAINE BT52 1SA, LONDONDERRY, NORTH IRELAND