Core-shell microencapsulation of curcumin in PLGA microparticles: programmed for application in ovarian cancer therapy

被引：30

作者：

Dwivedi, Pankaj ^{[1
]}

Yuan, Shuai ^{[1
,2
]}

Han, Shuya ^{[1
]}

Mangrio, Farhana Akbar ^{[1
]}

Zhu, Zhiqiang ^{[1
]}

Lei, Fan ^{[3
]}

Ming, Zhang ^{[1
]}

Cheng, Lei ^{[4
]}

Liu, Zhongfa ^{[5
]}

Si, Ting ^{[2
,3
]}

Xu, Ronald X. ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Dept Precis Machinery & Precis Instrumentat, Hefei, Anhui, Peoples R China

[2] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA

[3] Univ Sci & Technol China, Dept Modern Mech, Hefei, Anhui, Peoples R China

[4] Univ Sci & Technol China, Affiliated Hosp 1, Hefei, Anhui, Peoples R China

[5] Ohio State Univ, Coll Pharm, 500 W 12Th Ave, Columbus, OH 43210 USA

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2018年 / 46卷

基金：

中国国家自然科学基金;

关键词：

Microparticles; curcumin; sustained drug release; ovarian cancer; liquid-driven co-flow focusing; SUSTAINED-RELEASE; GENE-PRODUCTS; PHASE-I; NANOPARTICLES; APOPTOSIS; PROLIFERATION; SUPPRESSION; SOLUBILITY; ACTIVATION; PARTICLES;

D O I：

10.1080/21691401.2018.1499664

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In our study, we have established a novel liquid-driven co-flow focusing (LDCF) process to fabricate curcumin (CUR)-loaded poly (lactic-co-glycolic acid) (PLGA) microparticles (CPMs). LDCF-CPMs of size 20.26 +/- 2.37m have high encapsulation efficiency (>70%) and were intended for application in ovarian cancer by intraperitoneal (IP) administration. LDCF-CPMs have smooth surface with narrow size distribution and a core-shell structured verified by confocal microscopy which can be precisely controlled by changing the flow rates of focusing, outer and inner phases. The LDCF-CPMs reveal the physiochemical stability with sustained release profile corresponding to 95% CUR release over a period of 14days in an in vitro release medium. Moreover, LDCF-CPMs were testified for cytotoxicity against SKOV-3 ovarian cancer cell lines and peritoneal delivery advantages by animal experiments. The pharmacokinetics of LDCF-CPMs in rats following IP injection shows slow systemic absorption with mean residence time (MRT) of 13.54h in comparison with 9.82 and 6.74h for SE-CPMs and free CUR, respectively. In addition, IP delivery of CUR can expose the ovarian tumour to higher concentration for a longer duration by programming the thickness of the shell. The study provides compelling evidence for LDCF-CPMs having high therapeutic opportunity in the treatment of peritoneal cancers, such as ovarian, that reside in the peritoneal cavity.

引用

页码：S481 / S491

页数：11

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