Acute myeloid leukemia and NK cells: two warriors confront each other

被引：33
作者：
Baragano Raneros, Aroa [1 ]
Lopez-Larrea, Carlos [1 ,2 ]
Suarez-Alvarez, Beatriz [1 ]
机构：
[1] Hosp Univ Cent Asturias, Inst Invest Sanitaria Principado Asturias ISPA, Translat Immunol Lab, Av Roma S-N, Oviedo 33011, Spain
[2] Hosp Univ Cent Asturias, Immunol Dept, Oviedo, Spain
来源：
ONCOIMMUNOLOGY | 2019年 / 8卷 / 02期
关键词：
Acute myeloid leukemia; natural killer cells; NKG2D; CAR-T; immunotherapy; immune checkpoints; NATURAL-KILLER-CELL; CHIMERIC ANTIGEN RECEPTORS; NKG2D LIGAND EXPRESSION; T-CELLS; ACTIVATING RECEPTORS; EFFECTOR FUNCTIONS; VALPROIC ACID; STEM-CELLS; ANTITUMOR; CANCER;
D O I：
10.1080/2162402X.2018.1539617
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute myeloid leukemia (AML) is a heterogeneous disease whose therapies currently show elevated toxicity and a high rate of relapse. Recently, the burgeoning of new anti-tumor therapeutic strategies aimed at enhancing the immune response has pushed natural killer cells (NKs) into the spotlight. These cells are powerful warriors that can bring about the lysis of tumor cells through their cytotoxic ability. However, tumor cells have developed strategies to evade recognition mediated by NKs. Here, we review the mechanisms triggered by AML cells and discuss the emerging immunotherapeutic strategies that potentiate the anti-tumor functions of NKs.
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页数：11
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共 75 条
  • [31] CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
    Kenderian, S. S.
    Ruella, M.
    Shestova, O.
    Klichinsky, M.
    Aikawa, V.
    Morrissette, J. J. D.
    Scholler, J.
    Song, D.
    Porter, D. L.
    Carroll, M.
    June, C. H.
    Gill, S.
    [J]. LEUKEMIA, 2015, 29 (08) : 1637 - 1647
  • [32] A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression
    Kikushige, Yoshikane
    Miyamoto, Toshihiro
    Yuda, Junichiro
    Jabbarzadeh-Tabrizi, Siamak
    Shima, Takahiro
    Takayanagi, Shin-ichiro
    Niiro, Hiroaki
    Yurino, Ayano
    Miyawaki, Kohta
    Takenaka, Katsuto
    Iwasaki, Hiromi
    Akashi, Koichi
    [J]. CELL STEM CELL, 2015, 17 (03) : 341 - 352
  • [33] Licensing of natural killer cells by host major histocompatibility complex class I molecules
    Kim, S
    Poursine-Laurent, J
    Truscott, SM
    Lybarger, L
    Song, YJ
    Yang, LP
    French, AR
    Sunwoo, JB
    Lemieux, S
    Hansen, TH
    Yokoyama, WM
    [J]. NATURE, 2005, 436 (7051) : 709 - 713
  • [34] Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
    Klco, Jeffery M.
    Spencer, David H.
    Miller, Christopher A.
    Griffith, Malachi
    Lamprecht, Tamara L.
    O'Laughlin, Michelle
    Fronick, Catrina
    Magrini, Vincent
    Demeter, Ryan T.
    Fulton, Robert S.
    Eades, William C.
    Link, Daniel C.
    Graubert, Timothy A.
    Walter, Matthew J.
    Mardis, Elaine R.
    Dipersio, John F.
    Wilson, Richard K.
    Ley, Timothy J.
    [J]. CANCER CELL, 2014, 25 (03) : 379 - 392
  • [35] Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a Functional High-Affinity IL-2 Receptor on Human Cytokine-Induced Memory-like Natural Killer Cells
    Leong, Jeffrey W.
    Chase, Julie M.
    Romee, Rizwan
    Schneider, Stephanie E.
    Sullivan, Ryan P.
    Cooper, Megan A.
    Fehniger, Todd A.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (04) : 463 - 473
  • [36] Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV
    Liu, Dongfang
    Tian, Shuo
    Zhang, Kai
    Xiong, Wei
    Lubaki, Ndongala Michel
    Chen, Zhiying
    Han, Weidong
    [J]. PROTEIN & CELL, 2017, 8 (12) : 861 - 877
  • [37] Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers
    Liu, Y.
    Cheng, Y.
    Xu, Y.
    Wang, Z.
    Du, X.
    Li, C.
    Peng, J.
    Gao, L.
    Liang, X.
    Ma, C.
    [J]. ONCOGENE, 2017, 36 (44) : 6143 - 6153
  • [38] Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis
    Lu, Xuzhang
    Ohata, Kinya
    Kondo, Yukio
    Espinoza, J. Luis
    Qi, Zhirong
    Nakao, Shinji
    [J]. CANCER SCIENCE, 2010, 101 (03) : 609 - 615
  • [39] T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
    Mardiros, Armen
    Dos Santos, Cedric
    McDonald, Tinisha
    Brown, Christine E.
    Wang, Xiuli
    Budde, L. Elizabeth
    Hoffman, Lauren
    Aguilar, Brenda
    Chang, Wen-Chung
    Bretzlaff, William
    Chang, Brenda
    Jonnalagadda, Mahesh
    Starr, Renate
    Ostberg, Julie R.
    Jensen, Michael C.
    Bhatia, Ravi
    Forman, Stephen J.
    [J]. BLOOD, 2013, 122 (18) : 3138 - 3148
  • [40] Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    Miller, JS
    Soignier, Y
    Panoskaltsis-Mortari, A
    McNearney, SA
    Yun, GH
    Fautsch, SK
    McKenna, D
    Le, C
    Defor, TE
    Burns, LJ
    Orchard, PJ
    Blazar, BR
    Wagner, JE
    Slungaard, A
    Weisdorf, DJ
    Okazaki, IJ
    McGlave, PB
    [J]. BLOOD, 2005, 105 (08) : 3051 - 3057
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