Acute myeloid leukemia and NK cells: two warriors confront each other

被引：34

作者：

Baragano Raneros, Aroa ^{[1
]}

Lopez-Larrea, Carlos ^{[1
,2
]}

Suarez-Alvarez, Beatriz ^{[1
]}

机构：

[1] Hosp Univ Cent Asturias, Inst Invest Sanitaria Principado Asturias ISPA, Translat Immunol Lab, Av Roma S-N, Oviedo 33011, Spain

[2] Hosp Univ Cent Asturias, Immunol Dept, Oviedo, Spain

来源：

ONCOIMMUNOLOGY | 2019年 / 8卷 / 02期

关键词：

Acute myeloid leukemia; natural killer cells; NKG2D; CAR-T; immunotherapy; immune checkpoints; NATURAL-KILLER-CELL; CHIMERIC ANTIGEN RECEPTORS; NKG2D LIGAND EXPRESSION; T-CELLS; ACTIVATING RECEPTORS; EFFECTOR FUNCTIONS; VALPROIC ACID; STEM-CELLS; ANTITUMOR; CANCER;

D O I：

10.1080/2162402X.2018.1539617

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is a heterogeneous disease whose therapies currently show elevated toxicity and a high rate of relapse. Recently, the burgeoning of new anti-tumor therapeutic strategies aimed at enhancing the immune response has pushed natural killer cells (NKs) into the spotlight. These cells are powerful warriors that can bring about the lysis of tumor cells through their cytotoxic ability. However, tumor cells have developed strategies to evade recognition mediated by NKs. Here, we review the mechanisms triggered by AML cells and discuss the emerging immunotherapeutic strategies that potentiate the anti-tumor functions of NKs.

引用

页数：11

共 75 条

[1] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[2] Gene Mutations as Emerging Biomarkers and Therapeutic Targets for Relapsed Acute Myeloid Leukemia [J].

Aziz, Habsah ;

Ping, Chow Y. ;

Alias, Hamidah ;

Ab Mutalib, Nurul-Syakima ;

Jamal, Rahman .

FRONTIERS IN PHARMACOLOGY, 2017, 8

[3] Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia [J].

Baragano Raneros, A. ;

Martin-Palanco, V. ;

Fernandez, A. F. ;

Rodriguez, R. M. ;

Fraga, M. F. ;

Lopez-Larrea, C. ;

Suarez-Alvarez, B. .

GENES AND IMMUNITY, 2015, 16 (01) :71-82

[4] Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition [J].

Baragano Raneros, Aroa ;

Minguela Puras, Alfredo ;

Rodriguez, Ramon M. ;

Colado, Enrique ;

Bernal, Teresa ;

Anguita, Eduardo ;

Vasco Mogorron, Adela ;

Chaparro Gil, Alberto ;

Vidal-Castineira, J. R. ;

Marquez-Kisinousky, Leonardo ;

Diaz Bulnes, Paula ;

Martinez Marin, Amelia ;

Garcia Garay, Maria Carmen ;

Suarez-Alvarez, Beatriz ;

Lopez-Larrea, Carlos .

ONCOTARGET, 2017, 8 (19) :31959-31976

[5] Control of NK Cell Activation by Immune Checkpoint Molecules [J].

Beldi-Ferchiou, Asma ;

Caillat-Zucman, Sophie .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (10)

[6] The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody [J].

Benson, Don M., Jr. ;

Bakan, Courtney E. ;

Mishra, Anjali ;

Hofmeister, Craig C. ;

Efebera, Yvonne ;

Becknell, Brian ;

Baiocchi, Robert A. ;

Zhang, Jianying ;

Yu, Jianhua ;

Smith, Megan K. ;

Greenfield, Carli N. ;

Porcu, Pierluigi ;

Devine, Steven M. ;

Rotem-Yehudar, Rinat ;

Lozanski, Gerard ;

Byrd, John C. ;

Caligiuri, Michael A. .

BLOOD, 2010, 116 (13) :2286-2294

[7] In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors [J].

Berthon, Celine ;

Driss, Virginie ;

Liu, Jizhong ;

Kuranda, Klaudia ;

Leleu, Xavier ;

Jouy, Nathalie ;

Hetuin, Dominique ;

Quesnel, Bruno .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2010, 59 (12) :1839-1849

[8] Improved outcome for AML patients over the years 2000-2014 [J].

Bertoli, Sarah ;

Tavitian, Suzanne ;

Huynh, Anne ;

Borel, Cecile ;

Guenounou, Sarah ;

Luquet, Isabelle ;

Delabesse, Eric ;

Sarry, Audrey ;

Laurent, Guy ;

Attal, Michel ;

Huguet, Francoise ;

Berard, Emilie ;

Recher, Christian .

BLOOD CANCER JOURNAL, 2017, 7

[9] Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education [J].

Bjorkstrom, Niklas K. ;

Riese, Peggy ;

Heuts, Frank ;

Andersson, Sandra ;

Fauriat, Cyril ;

Ivarsson, Martin A. ;

Bjorklund, Andreas T. ;

Flodstrom-Tullberg, Malin ;

Michaelsson, Jakob ;

Rottenberg, Martin E. ;

Guzman, Carlos A. ;

Ljunggren, Hans-Gustaf ;

Malmberg, Karl-Johan .

BLOOD, 2010, 116 (19) :3853-3864

[10] Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia [J].

Chen, L. ;

Mao, H. ;

Zhang, J. ;

Chu, J. ;

Devine, S. ;

Caligiuri, M. A. ;

Yu, J. .

LEUKEMIA, 2017, 31 (08) :1830-1834

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