Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens

被引：254

作者：

Mekel-Bobrov, N

Gilbert, SL

Evans, PD

Vallender, EJ

Anderson, JR

Hudson, RR

Tishkoff, SA

Lahn, BT

机构：

[1] Univ Chicago, Howard Hughes Med Inst, Dept Human Genet, Chicago, IL 60637 USA

[2] Univ Chicago, Comm Genet, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[4] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

来源：

SCIENCE | 2005年 / 309卷 / 5741期

关键词：

D O I：

10.1126/science.1116815

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution.

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页码：1720 / 1722

页数：3

相关论文

共 13 条

[1] Signatures of natural selection in the human genome [J].

Bamshad, M ;

Wooding, SP .

NATURE REVIEWS GENETICS, 2003, 4 (02) :99-111A

[2] ASPM is a major determinant of cerebral cortical size [J].

Bond, J ;

Roberts, E ;

Mochida, GH ;

Hampshire, DJ ;

Scott, S ;

Askham, JM ;

Springell, K ;

Mahadevan, M ;

Crow, YJ ;

Markham, AF ;

Walsh, CA ;

Woods, CG .

NATURE GENETICS, 2002, 32 (02) :316-320

[3]

Cavalli-Sforza L. L., 1994, HIST GEOGRAPHY HUMAN

[4] Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans [J].

Evans, PD ;

Anderson, JR ;

Vallender, EJ ;

Gilbert, SL ;

Malcom, CM ;

Dorus, S ;

Lahn, BT .

HUMAN MOLECULAR GENETICS, 2004, 13 (05) :489-494

[5] Genetic links between brain development and brain evolution [J].

Gilbert, SL ;

Dobyns, WB ;

Lahn, BT .

NATURE REVIEWS GENETICS, 2005, 6 (07) :581-590

[6]

Houston S.D., 2004, The First Writing Script Invention as History and Process

[7] Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion [J].

Kouprina, N ;

Pavlicek, A ;

Mochida, GH ;

Solomon, G ;

Gersch, W ;

Yoon, YH ;

Collura, R ;

Ruvolo, M ;

Barrett, JC ;

Woods, CG ;

Walsh, CA ;

Jurka, J ;

Larionov, V .

PLOS BIOLOGY, 2004, 2 (05) :653-663

[8] Stratigraphic placement and age of modern humans from Kibish, Ethiopia [J].

McDougall, I ;

Brown, FH ;

Fleagle, JG .

NATURE, 2005, 433 (7027) :733-736

[9] A CELL-DIVISION MUTANT OF DROSOPHILA WITH A FUNCTIONALLY ABNORMAL SPINDLE [J].

RIPOLL, P ;

PIMPINELLI, S ;

VALDIVIA, MM ;

AVILA, J .

CELL, 1985, 41 (03) :907-912

[10] Genetic structure of human populations [J].

Rosenberg, NA ;

Pritchard, JK ;

Weber, JL ;

Cann, HM ;

Kidd, KK ;

Zhivotovsky, LA ;

Feldman, MW .

SCIENCE, 2002, 298 (5602) :2381-2385