Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b] [1,3,4] thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation

被引：92

作者：

Gomha, Sobhi M. ^{[1
]}

Riyadh, Sayed M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt

来源：

MOLECULES | 2011年 / 16卷 / 10期

关键词：

1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles; diazoles; Schiff's bases; microwave irradiation and antimicrobial activity; PHARMACOLOGICAL EVALUATION; DERIVATIVES;

D O I：

10.3390/molecules16108244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H- indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H-indoles 3a,b. Also, new [1,3,4]thiadiazoles 12a,b, [1,2,4]triazoles 15a,b and [1,3,4]oxadiazoles 19a,b, with indole moieties, were prepared by cyclization of 1-[(2-methyl-1H-indole)-3-carbonyl]thiosemicarbazides 8a,b under microwave irradiation using different reaction conditions. Moreover, reaction of acid hydrazide 7 with ethyl 2-(N-phenylhydrazono)-3-oxobutanoate (20) gave the respective phenylhydrazonopyrazole derivative 21 under the reaction conditions employed. The structures of the synthesized compounds were assigned based on elemental analyses and spectral data (IR, (1)H-NMR, (13)C-NMR, MS). The antifungal and antibacterial activities of the new products were also evaluated.

引用

页码：8244 / 8256

页数：13

共 22 条

[1]

Abdallah M.A., 2006, Int. J. Pure Appl. Chem, V1, P265

[2] Synthesis and biological activities of 7-arylazo-7H-pyrazolo[5,1-c][1,2,4] triazol-6(5H)-ones and 7-arylhydrazono-7H-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazines [J].