An NIR Discrete Metallacycle Constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for Imaging-Guided Cancer Radio-Chemotherapy

被引:110
作者
Ding, Yuan [1 ,2 ,3 ,4 ,5 ,6 ]
Tong, Zongrui [2 ,7 ]
Jin, Lulu [7 ]
Ye, Binglin [1 ,2 ,3 ,4 ,5 ,6 ]
Zhou, Jiong [8 ]
Sun, Zhongquan [1 ,2 ,3 ,4 ,5 ,6 ]
Yang, Huang [7 ]
Hong, Liangjie [7 ]
Huang, Feihe [9 ,10 ,11 ,12 ]
Wang, Weilin [1 ,2 ,3 ,4 ,5 ,6 ]
Mao, Zhengwei [1 ,2 ,7 ]
机构
[1] Zhejiang Univ, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
[2] Zhejiang Univ, Key Lab Precis Diag & Treatment Hepatobiliary & P, Hangzhou 310009, Zhejiang, Peoples R China
[3] Zhejiang Univ, Res Ctr Diag & Treatment Technol Hepatocellular C, Hangzhou 310009, Zhejiang, Peoples R China
[4] Zhejiang Univ, Clin Med Innovat Ctr Precis Diag & Treatment Hepa, Hangzhou 310009, Zhejiang, Peoples R China
[5] Zhejiang Univ, Clin Res Ctr Hepatobiliary & Pancreat Dis Zhejian, Hangzhou 310009, Zhejiang, Peoples R China
[6] Zhejiang Univ, Zhejiang Univ Canc Ctr, Hangzhou 310009, Zhejiang, Peoples R China
[7] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[8] Northeastern Univ, Dept Chem, Coll Sci, Shenyang 110819, Peoples R China
[9] Zhejiang Univ, Dept Chem, State Key Lab Chem Engn, Stoddart Inst Mol Sci,Key Lab Excited State Mat Z, Hangzhou 310027, Peoples R China
[10] ZJU Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 311215, Peoples R China
[11] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[12] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
基金
中国国家自然科学基金;
关键词
aggregation-induced emission; cancer theranostics; metallacycles; radio-chemotherapy; supramolecular chemistry; RESONANCE ENERGY-TRANSFER; TUMOR PENETRATION; GOLD NANORODS; DRUG-RELEASE; DELIVERY; NANOPARTICLES; CISPLATIN; THERAPY; STRATEGIES; SYSTEMS;
D O I
10.1002/adma.202106388
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
To promote the clinical theranostic performances of platinum-based anticancer drugs, imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be upgraded. Herein, a theranostic metallacycle (M) is developed for imaging-guided cancer radio-chemotherapy using perylene bisimide fluorophore (PPy) and tetraphenylethylene-based di-Pt(II) organometallic precursor (TPE-Pt) as building blocks. The formation of this discrete supramolecular coordination complex facilitates the encapsulation of M by a glutathione (GSH)-responsive amphiphilic block copolymer to prepare M-loaded nanoparticles (MNPs). TPE-Pt acts as a chemotherapeutic drug and also an excellent radiosensitizer, thus incorporating radiotherapy into the nanomedicine to accelerate the therapeutic efficacy and overcome drug resistance. The NIR-emission of PPy is employed to detect the intracellular delivery and tissue distribution of MNPs in real time. In vitro and in vivo investigations demonstrate the excellent anticancer efficacy combining chemotherapy and radiotherapy; the administration of this nanomedicine effectively inhibits the tumor growth and greatly extends the survival rate of cisplatin-resistant A2780CIS-tumor-bearing mice. Guided by in vivo fluorescence imaging, radio-chemotherapy is precisely carried out, which facilitates boosting of the therapeutic outcomes and minimizing undesired side effects. The success of this theranostic system brings new hope to supramolecular nanomedicines for their potential clinical translations.
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页数:14
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