Role of glutathione-S-transferase in tumor drug resistance

被引：3
作者：
Gorozhanskaya, EG [1 ]
Korolova, EY [1 ]
Egorova, NI [1 ]
Larionova, VB [1 ]
Garin, AM [1 ]
Kushlinskii, NE [1 ]
机构：
[1] Russian Acad Med Sci, NN Blokhin Oncol Res Ctr, Lab Clin Biochem, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1998年 / 125卷 / 05期
关键词：
glutathione; glutathione-S-transferase; tumor patients; resistance;
D O I：
10.1007/BF02445296
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The content of glutathione and glutathione-S-transferase activity in erythrocytes are determined in patients with testicular and ovarian cancer and melanoma before and after chemotherapy. The initial levels of glutathione and glutathione-S-transferase activity in patients susceptible to drug therapy are substantially lower than in drug-resistant patients. Complex platinum-based chemotherapy increases the content of glutathione and inhibits glutathione-S-transferase in patients with drug-sensitive tumors; in patients resistant to chemotherapy, the content of glutathione decreases, while glutathione-S-transferase activity remains practically unchanged. High levels of glutathione and glutathione-S-transferase activity in tumor patients can be used as the measure and prognostic criteria of drug resistance.
引用
收藏
页码：499 / 502
页数：4
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