An Overview of the Bacterial Carbonic Anhydrases

被引：171

作者：

Supuran, Claudiu T. ^{[1
]}

Capasso, Clemente ^{[2
]}

机构：

[1] Univ Firenze, Polo Sci, Lab Chim Bioinorgan, Dipartimento Neurofarba,Sez Sci Farmaceut, Via U Schiff 6, I-50019 Florence, Italy

[2] CNR, Ist Biosci & Biorisorse IBBR, Via Pietro Castellino 111, I-80131 Naples, Italy

来源：

METABOLITES | 2017年 / 7卷 / 04期

关键词：

bacterial carbonic anhydrases; inhibitors; antibiotic; CO2; capture; engineered bacteria; SULFURIHYDROGENIBIUM-YELLOWSTONENSE YO3AOP1; SULFONAMIDE INHIBITION PROFILES; PATHOGEN STREPTOCOCCUS-MUTANS; VIBRIO-CHOLERAE; ANION INHIBITION; HELICOBACTER-PYLORI; MYCOBACTERIUM-TUBERCULOSIS; CRYSTAL-STRUCTURE; DRUG TARGETS; AMINO-ACIDS;

D O I：

10.3390/metabo7040056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the alpha-, beta-, and gamma- classes. By equilibrating CO2 and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO2 capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action.

引用

页数：19

共 104 条

[21] Structural mechanics of the pH-dependent activity of β-carbonic anhydrase from Mycobacterium tuberculosis [J].

Covarrubias, AS ;

Bergfors, T ;

Jones, TA ;

Högbom, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (08) :4993-4999

[22] Cloning, crystallization and preliminary characterization of a β-carbonic anhydrase from Escherichia coli [J].

Cronk, JD ;

O'Neill, JW ;

Cronk, MR ;

Endrizzi, JA ;

Zhang, KYJ .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2000, 56 :1176-1179

[23] Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors [J].

De Luca, Laura ;

Ferro, Stefania ;

Damiano, Francesca M. ;

Supuran, Claudiu T. ;

Vullo, Daniela ;

Chimirri, Alba ;

Gitto, Rosaria .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 71 :105-111

[24] Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense [J].

De Simone, Giuseppina ;

Monti, Simona Maria ;

Alterio, Vincenzo ;

Buonanno, Martina ;

De Luca, Viviana ;

Rossi, Mose ;

Carginale, Vincenzo ;

Supuran, Claudiu T. ;

Capasso, Clemente ;

Di Fiore, Anna .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (09) :2002-2006

[25] Bad Bugs, No Drugs: Are We Part of the Problem, or Leaders in Developing Solutions? [J].

Decker, Brooke ;

Masur, Henry .

CRITICAL CARE MEDICINE, 2015, 43 (06) :1153-1155

[26] Cloning, characterization and anion inhibition study of a β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans [J].

Dedeoglu, Nurcan ;

De Luca, Viviana ;

Isik, Semra ;

Yildirim, Hatice ;

Kockar, Feray ;

Capasso, Clemente ;

Supuran, Claudiu T. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (13) :2995-3001

[27] Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans [J].

Dedeoglu, Nurcan ;

DeLuca, Viviana ;

Isik, Semra ;

Yildirim, Hatice ;

Kockar, Feray ;

Capasso, Clemente ;

Supuran, Claudiu T. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (11) :2291-2297

[28] A one-step procedure for immobilising the thermostable carbonic anhydrase (SspCA) on the surface membrane of Escherichia coli [J].

Del Prete, Sonia ;

Perfetto, Rosa ;

Rossi, Mose ;

Alasmary, Fatmah A. S. ;

Osman, Sameh M. ;

AlOthman, Zeid ;

Supuran, Claudiu T. ;

Capasso, Clemente .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2017, 32 (01) :1120-1128

[29] Sulfonamide inhibition profiles of the β-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia [J].

Del Prete, Sonia ;

Vullo, Daniela ;

Osman, Sameh M. ;

AlOthman, Zeid ;

Supuran, Claudiu T. ;

Capasso, Clemente .

BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (13) :3555-3561

[30] Cloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium fakiparum [J].

Del Prete, Sonia ;

De Luca, Viviana ;

De Simone, Giuseppina ;

Supuran, Claudiu T. ;

Capasso, Clemente .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 :54-59

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