An Overview of the Bacterial Carbonic Anhydrases

被引：171

作者：

Supuran, Claudiu T. ^{[1
]}

Capasso, Clemente ^{[2
]}

机构：

[1] Univ Firenze, Polo Sci, Lab Chim Bioinorgan, Dipartimento Neurofarba,Sez Sci Farmaceut, Via U Schiff 6, I-50019 Florence, Italy

[2] CNR, Ist Biosci & Biorisorse IBBR, Via Pietro Castellino 111, I-80131 Naples, Italy

来源：

METABOLITES | 2017年 / 7卷 / 04期

关键词：

bacterial carbonic anhydrases; inhibitors; antibiotic; CO2; capture; engineered bacteria; SULFURIHYDROGENIBIUM-YELLOWSTONENSE YO3AOP1; SULFONAMIDE INHIBITION PROFILES; PATHOGEN STREPTOCOCCUS-MUTANS; VIBRIO-CHOLERAE; ANION INHIBITION; HELICOBACTER-PYLORI; MYCOBACTERIUM-TUBERCULOSIS; CRYSTAL-STRUCTURE; DRUG TARGETS; AMINO-ACIDS;

D O I：

10.3390/metabo7040056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the alpha-, beta-, and gamma- classes. By equilibrating CO2 and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO2 capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action.

引用

页数：19

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