Potential silicon-containing antifolates

被引：10
|
作者：
Taylor, EC [1 ]
Chaudhuri, RP
Watson, SE
机构：
[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
[2] Long Isl Univ, Dept Chem, Brooklyn, NY 11201 USA
来源：
TETRAHEDRON | 1999年 / 55卷 / 06期
关键词：
antitumor compounds; coupling reactions; enzyme inhibitors; silicon compounds;
D O I：
10.1016/S0040-4020(98)01207-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel silicon-containing folate derivatives were synthesized as potential inhibitors of folate-dependent enzymes in an attempt to develop more effective antitumor agents. A dimethylsilyl moiety was inserted into the sidechain of two known antifolates with the aim of improving passive transport properties and sidechain conformational flexibility. An efficient, convergent palladium-catalyzed coupling methodology was used to link known heterocycles to novel, highly functionalized vinyl and ethynyl silanes. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1631 / 1638
页数：8
相关论文
共 50 条
  • [41] SYNTHESIS OF SILICON-CONTAINING ACETYLENIC YLIDE AND ITS 1,3-ENYNE SILICON-CONTAINING HYDROCARBONS
    BELYAEV, NN
    BELYAEV, AN
    STADNICH.MD
    PETROV, AA
    ZHURNAL OBSHCHEI KHIMII, 1972, 42 (03): : 715 - &
  • [42] Studies of Silicon-Containing Bismaleimide Resins - Preparation and Characteristics of Reactive Blends of Silicon-Containing Bismaleimide and Epoxy
    Tsai, R. S.
    Wang, Z. Y.
    Shu, W. J.
    INTERNATIONAL POLYMER PROCESSING, 2010, 25 (02) : 125 - 131
  • [43] PREPARATION AND PROPERTIES OF SILICON-CONTAINING POLYIMIDES
    TSUTSUMI, N
    TSUJI, A
    HORIE, C
    KIYOTSUKURI, T
    EUROPEAN POLYMER JOURNAL, 1988, 24 (09) : 837 - 841
  • [44] Silicon-containing dimethylphosphoric acid amides
    Lazareva, N. F.
    Albanov, A. I.
    Lazarev, I. M.
    Pestunovich, V. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 43 (08) : 1130 - 1133
  • [45] SEMICONDUCTIVE PROPERTIES OF SILICON-CONTAINING POLYMERS
    NOVIKOVA, OA
    UKRAINSKII KHIMICHESKII ZHURNAL, 1973, 39 (12): : 1270 - 1273
  • [46] CHEMICAL PROPERTIES OF SILICON-CONTAINING CYANURATES
    GORDETSOV, AS
    VOSTOKOV, IA
    DERGUNOV, YI
    ZHURNAL OBSHCHEI KHIMII, 1977, 47 (02): : 372 - 376
  • [47] HYDROPEROXIDE EPOXYDATION OF SILICON-CONTAINING OLEFINS
    GAILYUNAS, IA
    TSYRLINA, EM
    SOLOVEVA, NI
    KOMALENKOVA, NG
    YUREV, VP
    ZHURNAL OBSHCHEI KHIMII, 1977, 47 (10): : 2394 - 2395
  • [48] NEW AROMATIC SILICON-CONTAINING POLYAMIDES
    PRATT, JR
    JOHNSTON, NJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1975, 170 (AUG24): : 29 - 29
  • [49] SYNTHESIS OF SILICON-CONTAINING DIETHYLENE DIKETONES
    GVERDTSITELI, IM
    GOGESASHVILI, NN
    DOKSOPULO, TP
    ZHURNAL OBSHCHEI KHIMII, 1978, 48 (05): : 1113 - 1116
  • [50] MICROHARDNESS OF SILICON-CONTAINING PYROLYTIC CARBON
    TUKOVIC, A
    MARINKOV.S
    JOURNAL OF MATERIALS SCIENCE, 1970, 5 (07) : 541 - &
12345