Inhibitory effects of Shuanghuanglian injection on nuclear factor-kappa B expression in mice with viral encephalitis in a time- and dose-dependent manner

被引：2
|
作者：
Tian, Ye [1 ]
Han, Caiping [1 ]
Gu, Naibing [1 ]
Di, Zhengli [1 ]
Zhang, Gejuan [1 ]
Lei, Hui [1 ]
机构：
[1] Xian Ctr Hosp, Dept Neurol, Xian 710003, Shaanxi Provinc, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 24期
关键词：
nuclear factor-kappa B; viral encephalitis; mice; gene expression; Shuanghuanglian injection; neural regeneration; GENE-EXPRESSION; SCIATIC-NERVE; MOUSE MODEL; INFECTION; APOPTOSIS; VIRUS; BRAIN; IMMUNOGLOBULIN; DISEASES; THERAPY;
D O I：
10.3969/j.issn.1673-5374.2011.24.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Previous studies have confirmed that the anti-virus effects of Shuanghuanglian injection may be associated with nuclear factor-kappa B activity. This study observed nuclear factor-kappa B expression in mice with viral encephalitis, and showed significant decreases in nuclear factor-kappa B protein and mRNA levels following Shuanghuanglian injection. The inhibitory effect was more significant with prolonged intervention duration and increased treatment dose. These findings verify that Shuanghuanglian injection plays a therapeutic role in viral encephalitis by reducing expression of nuclear factor-kappa B in a time- and dose-dependent manner.
引用
收藏
页码：1865 / 1869
页数：5
相关论文
共 22 条
  • [11] Time Course of Colonic Nuclear Factor-Kappa B Expression During Bacterial Peptidoglycan–Polysaccharide-Induced Colitis in Rats
    Leo R. Fitzpatrick
    Jian Wang
    Truc Le
    Noel Calingasan
    Digestive Diseases and Sciences, 2003, 48 : 775 - 782
  • [12] Time course of colonic nuclear factor-kappa B expression during bacterial peptidoglycan-polysaccharide-induced colitis in rats
    Fitzpatrick, LR
    Wang, J
    Le, T
    Calingasan, N
    DIGESTIVE DISEASES AND SCIENCES, 2003, 48 (04) : 775 - 782
  • [13] Effects of transplantation of microencapsulated rabbit sciatic nerve on nuclear factor-kappa B expression after spinal cord injury in rats
    Xiaolian Wang
    Neural Regeneration Research, 2009, 4 (03) : 213 - 217
  • [14] Effects of transplantation of microencapsulated rabbit sciatic nerve on nuclear factor-kappa B expression after spinal cord injury in rats
    Wang, Xiaolian
    Ma, Jianmin
    Chen, Hui
    Liu, Deming
    NEURAL REGENERATION RESEARCH, 2009, 4 (03) : 213 - 217
  • [15] Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice
    Roy, Preeti
    Nigam, Nidhi
    Singh, Madhulika
    George, Jasmine
    Srivastava, Smita
    Naqvi, Hasnain
    Shukla, Yogeshwer
    INVESTIGATIONAL NEW DRUGS, 2010, 28 (04) : 466 - 471
  • [16] c-FLIPp43 induces activation of the nuclear factor-κB signaling pathway in a dose-dependent manner in the A375 melanoma cell line
    Wang, Yujue
    Tu, Yating
    Lu, Jiejie
    Tao, Juan
    Li, Yan
    MOLECULAR MEDICINE REPORTS, 2014, 10 (03) : 1438 - 1442
  • [17] Comparative Inhibitory Effects of Magnolol, Honokiol, Eugenol and bis-Eugenol on Cyclooxygenase-2 Expression and Nuclear Factor-Kappa B Activation in RAW264.7 Macrophage-like Cells Stimulated with Fimbriae of Porphyromonas gingivalis
    Murakami, Yukio
    Kawata, Akifumi
    Seki, Yuya
    Koh, Teho
    Yuhara, Kenji
    Maruyama, Takehisa
    Machino, Mamoru
    Ito, Shgeru
    Kadoma, Yoshinori
    Fujisawa, Seiichiro
    IN VIVO, 2012, 26 (06): : 941 - 950
  • [18] Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/betacatenin signaling in colons of BALB/c mice
    Ajayi, Babajide O.
    Adedara, Isaac A.
    Farombi, Ebenezer O.
    FOOD AND CHEMICAL TOXICOLOGY, 2016, 95 : 42 - 51
  • [19] Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury
    Wang, Hongxin
    Zhang, Kan
    Zhao, Lan
    Tang, Jiangwei
    Gao, Luyan
    Wei, Zhongping
    NEUROSCIENCE LETTERS, 2014, 566 : 247 - 251
  • [20] HIV-1 gp120 Induces Expression of IL-6 through a Nuclear Factor-Kappa B-Dependent Mechanism: Suppression by gp120 Specific Small Interfering RNA
    Shah, Ankit
    Verma, Ashish S.
    Patel, Kalpeshkumar H.
    Noel, Richard
    Rivera-Amill, Vanessa
    Silverstein, Peter S.
    Chaudhary, Suman
    Bhat, Hari K.
    Stamatatos, Leonidas
    Singh, Dhirendra P.
    Buch, Shilpa
    Kumar, Anil
    PLOS ONE, 2011, 6 (06):
123