Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

被引：19

作者：

Jang, Hyun-Jae ^{[1
,2
]}

Oh, Hyun-Mee ^{[1
]}

Hwang, Joo Tae ^{[1
]}

Kim, Mi-Hwa ^{[1
]}

Lee, Soyoung ^{[1
]}

Jung, Kyungsook ^{[1
]}

Kim, Young-Ho ^{[2
]}

Lee, Seung Woong ^{[1
]}

Rho, Mun-Chual ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Nat Prod Res Ctr, 181 Ipsin Gil, Jeongeup Si 56212, Jeonbuk, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

来源：

PHYTOCHEMISTRY | 2016年 / 130卷

关键词：

Salvia plebeia; Lamiaceae; Eudesmane sesquiterpenoids; IL-6; STAT3; Inflammation; ABSOLUTE-CONFIGURATION; SIGNAL TRANSDUCER; LINDERA-STRYCHNIFOLIA; CANCER; CELLS; LACTONES; EXTRACT; INTERLEUKIN-6; INFLAMMATION; ANTIOXIDANT;

D O I：

10.1016/j.phytochem.2016.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：335 / 342

页数：8

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