Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

被引：19

作者：

Jang, Hyun-Jae ^{[1
,2
]}

Oh, Hyun-Mee ^{[1
]}

Hwang, Joo Tae ^{[1
]}

Kim, Mi-Hwa ^{[1
]}

Lee, Soyoung ^{[1
]}

Jung, Kyungsook ^{[1
]}

Kim, Young-Ho ^{[2
]}

Lee, Seung Woong ^{[1
]}

Rho, Mun-Chual ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Nat Prod Res Ctr, 181 Ipsin Gil, Jeongeup Si 56212, Jeonbuk, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

来源：

PHYTOCHEMISTRY | 2016年 / 130卷

关键词：

Salvia plebeia; Lamiaceae; Eudesmane sesquiterpenoids; IL-6; STAT3; Inflammation; ABSOLUTE-CONFIGURATION; SIGNAL TRANSDUCER; LINDERA-STRYCHNIFOLIA; CANCER; CELLS; LACTONES; EXTRACT; INTERLEUKIN-6; INFLAMMATION; ANTIOXIDANT;

D O I：

10.1016/j.phytochem.2016.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：335 / 342

页数：8

共 50 条

[1] Anti-inflammatory Activity of Eudesmane-Type Sesquiterpenoids from Salvia plebeia
Jang, Hyun-Jae
Lee, Soyoung
Lee, Seung-Jae
Lim, Hyung-Jin
Jung, Kyungsook
Kim, Young Ho
Lee, Seung Woong
Rho, Mun-Chual
JOURNAL OF NATURAL PRODUCTS, 2017, 80 (10): : 2666 - 2676
[2] Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation
Jang, Hyun-Jae
Lee, Seung-Jae
Lee, Soyoung
Jung, Kyungsook
Lee, Seung Woong
Rho, Mun-Chual
MOLECULES, 2017, 22 (10)
[3] Inhibitory effects of IL-6-induced STAT3 activation of bio-active compounds derived from Salvia plebeia R.Br
Lee, Seung-Jae
Jang, Hyun-Jae
Kim, Yesol
Oh, Hyun-Mee
Lee, Soyoung
Jung, Kyungsook
Kim, Young-Ho
Lee, Woo-Song
Lee, Seung-Woong
Rho, Mun Chual
PROCESS BIOCHEMISTRY, 2016, 51 (12) : 2222 - 2229
[4] Phenolic Compounds Isolated from Psoralea corylifolia Inhibit IL-6-induced STAT3 Activation
Lee, Seung Woong
Yun, Bo Ra
Kim, Mi Hwa
Park, Chan Sun
Lee, Woo Song
Oh, Hyun-Mee
Rho, Mun-Chual
PLANTA MEDICA, 2012, 78 (09) : 903 - 906
[5] Diarylheptanoids from Curcuma phaeocaulis Suppress IL-6-Induced STAT3 Activation
Jang, Hyun-Jae
Park, Eun-Jae
Lee, Seung-Jae
Lim, Hyung-Jin
Jo, Jin Ha
Lee, Seung Woong
Rho, Mun-Chual
PLANTA MEDICA, 2019, 85 (02) : 94 - 102
[6] Kansuinine A and Kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 Activation
Chang, Jong Sun
Lee, Seung Woong
Park, Mi Hye
Kim, Myo Sun
Hudson, Barry I.
Park, Su-Jin
Lee, Woo Song
Rho, Mun-Chual
PLANTA MEDICA, 2010, 76 (14) : 1544 - 1549
[7] LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
Bode, JG
Nimmesgern, A
Schmitz, J
Schaper, F
Schmitt, M
Frisch, W
Hussinger, D
Heinrich, PC
Graeve, L
FEBS LETTERS, 1999, 463 (03) : 365 - 370
[8] Inhibition of IL-6-induced STAT3 Activation by Pimaradienoic Acid from Aralia continentalis
Oh, Tae-Seok
Bae, Eun Young
Kim, Mi Hwa
Oh, Hyun-Mee
Lee, Seung Woong
Kim, Chang-Ho
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2014, 35 (12) : 3661 - 3664
[9] PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction
Kato, Masaya
Muromoto, Ryuta
Togi, Sumihito
Iwakami, Masashi
Kitai, Yuichi
Kon, Shigeyuki
Oritani, Kenji
Matsuda, Tadashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 461 (02) : 366 - 371
[10] INHIBITION OF IL-6-INDUCED STAT3 ACTIVATION IN MYELOMA CELLS BY PROTEIN KINASE A
宋伦
黎燕
沈倍奋
ChineseJournalofCancerResearch, 2001, (04) : 12 - 15

← 1 2 3 4 5 →