Polynucleotide kinase 3′ phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial

被引：1

作者：

Murphy, Gwen ^{[1
,2
,3
]}

Sansbury, Leah S. ^{[2
,3
]}

Bergen, Andrew W. ^{[1
]}

Wang, Zhuoqiao ^{[4
]}

Schatzkin, Arthur ^{[1
]}

Lehman, Teresa ^{[5
]}

Kalidindi, Aravind ^{[5
]}

Modali, Rama ^{[5
]}

Lanza, Elaine ^{[3
]}

机构：

[1] NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[2] NCI, Canc Prevent Fellowship Program, Off Prevent Oncol, Bethesda, MD 20892 USA

[3] NCI, Ctr Canc Res, Bethesda, MD 20892 USA

[4] Informat Management Serv Inc, Rockville, MD USA

[5] Bioserve Biotechnol Ltd, Laurel, MD USA

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 2008年 / 17卷 / 03期

关键词：

adenoma; diet; DNA repair; polyp prevention trial;

D O I：

10.1097/CEJ.0b013e3282b6fdb8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polymorphisms in a number of genes encoding for DNA repair enzymes have been associated with altering the function of these enzymes and increasing risk of a number of cancers, including colon cancer. We have investigated the association between a common variant in polynucleotide kinase 3' phosphatase (PNKP), a putative DNA repair enzyme, and risk of adenoma recurrence in the Polyp Prevention Trial participants. We also investigated possible interaction or effect modification between carriage of the variant allele, dietary components and risk of adenoma recurrence. Unconditional logistic regression models were used to calculate the odds ratios and 95% confidence intervals for an association between the G/T polymorphism, PNKP T5644G and risk of adenoma recurrence. We observed no association between carriage of the variant allele and risk of adenoma recurrence. Furthermore, we found no effect modification between genotype, dietary components and risk of adenoma recurrence. The PNKP T5644G variant does not seem to be involved in adenoma recurrence in the Polyp Prevention Trial.

引用

页码：287 / 290

页数：4

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