Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission

被引：16

作者：

Calton, JL

Wilson, WA

Moore, SD

机构：

[1] Duke Univ, Med Ctr, Durham VA Med Ctr, Dept Psychiat, Durham, NC 27705 USA

[2] Duke Univ, Med Ctr, Div Psychiat, Durham, NC USA

[3] Duke Univ, Med Ctr, Div Neurol Res, Durham, NC USA

[4] Duke Univ, Med Ctr, Durham VA Med Ctr, Dept Pharmacol, Durham, NC 27705 USA

来源：

BRAIN RESEARCH | 1999年 / 816卷 / 01期

关键词：

basolateral amygdala; calcium channel; ethanol; N-methyl-D-aspartate;

D O I：

10.1016/S0006-8993(98)01144-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown inhibitory effects of EtOH on NMDA receptor-mediated synaptic transmission in several brain regions. We examined this effect of EtOH under both current clamp and voltage clamp conditions in the basolateral amygdala because of the putative role of the amygdala in mediating anxiolytic effects of EtOH. We found that EtOH reduced NMDA receptor-mediated synaptic responses. In addition, we found that NMDA receptor-mediated depolarizations could also activate a voltage-dependent regenerative potential which was also sensitive to EtOH. Pharmacological characterization of this current was consistent with a high-threshold Ca2+ current. This current also exhibited a pronounced tendency towards transient enhancement upon withdrawal of EtOH. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：142 / 148

页数：7

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